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https://olympias.lib.uoi.gr/jspui/handle/123456789/24467Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Haidich, A. B. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:41:17Z | - |
| dc.date.available | 2015-11-24T19:41:17Z | - |
| dc.identifier.issn | 0895-4356 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24467 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Clinical Trials as Topic/*methods | en |
| dc.subject | HIV Infections/therapy | en |
| dc.subject | Humans | en |
| dc.subject | Logistic Models | en |
| dc.subject | Multicenter Studies as Topic/*methods | en |
| dc.subject | *Patient Selection | en |
| dc.subject | Randomized Controlled Trials as Topic/methods | en |
| dc.subject | Research Design | en |
| dc.title | The Gini coefficient as a measure for understanding accrual inequalities in multicenter clinical studies | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.jclinepi.2003.09.011 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15135834 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0895435603003743/1-s2.0-S0895435603003743-main.pdf?_tid=1695aa9628ef772f56f45584e9bd13ed&acdnat=1333364442_5033404ec884136cc3363210bb3d4dee | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2004 | - |
| heal.abstract | OBJECTIVE: Clinical sites participating in multicenter trials may have unequal performance in recruiting subjects. We propose using the Gini coefficient as a quantitative measure of site accrual inequalities. STUDY DESIGN AND SETTING: We evaluated the relationship of this metric to other study characteristics across 166 clinical studies (27,865 subjects) conducted by the AIDS Clinical Trials Group between 1986 and 1999. RESULTS: Overall there was a modest recruitment inequality among clinical centers (mean Gini=0.33). In multivariate modeling, site accrual inequalities were higher when there was more protracted enrollment, and a larger number of sites and were lower in antiretroviral studies than other studies. In long-term studies, the site accrual inequality increased significantly over time (P=0.004). In efficacy trials, a higher Gini coefficient was associated with higher likelihood of the study results being statistically significant (P=0.010). CONCLUSION: The Gini coefficient may be easily and routinely incorporated in the description of the characteristics of a clinical study and may provide insights about its enrollment pattern. | en |
| heal.journalName | J Clin Epidemiol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Haidich-2004-The Gini coefficient.pdf | 305.06 kB | Adobe PDF | View/Open Request a copy |
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