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https://olympias.lib.uoi.gr/jspui/handle/123456789/24394Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Giotopoulou, S. | en |
| dc.contributor.author | Dokou, E. | en |
| dc.contributor.author | Tzoufi, M. | en |
| dc.contributor.author | Kolaitis, N. | en |
| dc.contributor.author | Vartholomatos, G. | en |
| dc.date.accessioned | 2015-11-24T19:40:43Z | - |
| dc.date.available | 2015-11-24T19:40:43Z | - |
| dc.identifier.issn | 0392-9078 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24394 | - |
| dc.rights | Default Licence | - |
| dc.subject | B-Lymphocytes/immunology/*metabolism/pathology | en |
| dc.subject | Cell Lineage | en |
| dc.subject | Child | en |
| dc.subject | Female | en |
| dc.subject | Flow Cytometry | en |
| dc.subject | HLA-DR Antigens/*analysis/immunology | en |
| dc.subject | Humans | en |
| dc.subject | Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology/*metabolism/pathology | en |
| dc.subject | Stem Cells/immunology/*metabolism/pathology | en |
| dc.title | A case of HLA-DR negative B-precursor acute lymphoblastic leukemia | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15053308 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2003 | - |
| heal.abstract | We present the case of a 9-year-old girl from northwestern Greece admitted to our Hospital because of malaise, low-grade fever, intermittent hip joint pain, anemia, leukopenia and thrombocytopenia. The examination of a bone marrow aspirate revealed the predominance of blast cells (97%) with FAB L1 morphology, immunopheno-typically positive for CD19 (95%), CD10 (95%), CD22 (95%), CD13 (82%), CD34 (95%) and CD38 (72%), with dim expression of CD45 and of the intracellular antigen terminal deoxynucleotidyl transferase (Tdt). Only 10% of the blasts expressed HLA-DR. Staining for CD2, CD3, CD5, CD7, CD20, CD23, CD33, CD14, CD15, AC133 and KOR-SA3544 was negative. Blast cells were lacking surface immunoglobulin expression and bcr/abl rearrangements were not detected. Cell cycle analysis revealed a diploid cell population. Karyotypic abnormalities were not identified. The lack of expression of HLA-DR and the presence of myeloid antigen CD13 indicated that it was a rare case of B-precursor ALL with aberrant immunophenotypic characteristics. | en |
| heal.journalName | J Exp Clin Cancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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