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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24279
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dc.contributor.authorKalantaridou, S. N.en
dc.contributor.authorCalis, K. A.en
dc.contributor.authorMazer, N. A.en
dc.contributor.authorGodoy, H.en
dc.contributor.authorNelson, L. M.en
dc.date.accessioned2015-11-24T19:39:55Z-
dc.date.available2015-11-24T19:39:55Z-
dc.identifier.issn0021-972X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24279-
dc.rightsDefault Licence-
dc.subjectAdministration, Cutaneousen
dc.subjectAdulten
dc.subjectAndrogens/*administration & dosage/adverse effects/therapeutic useen
dc.subjectFemaleen
dc.subjectHormones/blooden
dc.subjectHumansen
dc.subjectMenstrual Cycle/drug effectsen
dc.subjectPilot Projectsen
dc.subjectPrimary Ovarian Insufficiency/blood/*drug therapy/physiopathologyen
dc.subjectTestosterone/*administration & dosage/adverse effects/therapeutic useen
dc.titleA pilot study of an investigational testosterone transdermal patch system in young women with spontaneous premature ovarian failureen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1210/jc.2005-0692-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16174721-
heal.identifier.secondaryhttp://jcem.endojournals.org/content/90/12/6549.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2005-
heal.abstractCONTEXT: Evidence suggests that young women with spontaneous premature ovarian failure (sPOF) have significantly lower androgen levels than age-matched regularly menstruating women. OBJECTIVE: The objective of the study was to evaluate an investigational testosterone transdermal patch (TTP) designed to deliver the normal ovarian production rate of testosterone. DESIGN: This was an open-label study (2-month baseline period followed by 2-month treatment period). PATIENTS: Nine women with sPOF and a history of regular bleeding patterns on standard estrogen/progestogen cyclic treatment participated in the study. One subject with abnormal baseline levels was excluded. INTERVENTION: Four consecutive 28-d cycles of transdermal estradiol (E2; 0.1 mg/d) and sequential oral medroxyprogesterone acetate (MPA; 10 mg/d for the last 12 d of each cycle). During cycles 3 and 4, an investigational TTP (nominal delivery 150 microg/d) was applied twice weekly to the abdomen. MAIN OUTCOME MEASURES: Steady-state pharmacokinetic profiles of free and total testosterone and scheduled vaginal bleeding patterns were studied. RESULTS: The mean (95% confidence interval) of the time-average free testosterone levels during TTP treatment was 7.5 (4.9-9.9) pg/ml; 26.0 (17.2-34.6) pmol/liter (with E2), and 6.9 (4.9-8.8) pg/ml; 23.9 (17.2-30.5) pmol/liter (with E2 and MPA). The confidence intervals of the means include the upper limit of normal for premenopausal women, i.e. 6.8 pg/ml (23.5 pmol/liter), although the mean values are slightly above this. CONCLUSIONS: The addition of TTP to cyclic E2/MPA therapy in women with sPOF produced mean free testosterone levels that approximate the upper limit of normal. A 3-yr study to assess safety and effectiveness in this population is in progress.en
heal.journalNameJ Clin Endocrinol Metaben
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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