Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/24266Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kanavaros, P. | en |
| dc.contributor.author | Lavergne, A. | en |
| dc.contributor.author | Galian, A. | en |
| dc.contributor.author | Boivin, P. | en |
| dc.contributor.author | Fourmestreaux, A. R. | en |
| dc.contributor.author | Priollet, B. C. | en |
| dc.contributor.author | Flandrin, G. | en |
| dc.contributor.author | Hautefeuille, P. | en |
| dc.date.accessioned | 2015-11-24T19:39:40Z | - |
| dc.date.available | 2015-11-24T19:39:40Z | - |
| dc.identifier.issn | 0147-5185 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24266 | - |
| dc.rights | Default Licence | - |
| dc.subject | Cytoplasmic Granules/ultrastructure | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Intestinal Neoplasms/enzymology/surgery/*ultrastructure | en |
| dc.subject | Lymphoma, Non-Hodgkin/enzymology/surgery/*ultrastructure | en |
| dc.subject | Male | en |
| dc.subject | Microscopy, Electron | en |
| dc.subject | Middle Aged | en |
| dc.subject | Neoplasm Invasiveness | en |
| dc.title | A primary immunoblastic T malignant lymphoma of the small bowel, with azurophilic intracytoplasmic granules. A histologic, immunologic, and electron microscopy study | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/3400792 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1988 | - |
| heal.abstract | We report an aggressive primary T-immunoblastic lymphoma of the small intestine without blood involvement or associated celiac disease. Grossly, the tumor was composed of multiple disseminated ulcerated, infiltrating, or protuberant nodular lesions. Immunologic investigation showed that lymphoma cells were of peripheral (post-thymic) T-cell origin and expressed the phenotype associated with cytotoxic-suppressor subset (Leu4/CD3+, Leu9/CD7+, Leu2/CD8+, Leu11/CD16+, Leu 7/NKcells+, FcIgG+, HLA-DR+, anti-Tac/CD25+, Ki-1/CD30-, Leu1/CD5-, Leu5/CD2-, Leu3/CD4-). A particular morphologic feature of this case is the presence of numerous azurophilic granules within the lymphoma cells, identified as lysosomes by cytochemical and ultrastructural studies. In view of recent immunologic evidence that normal cytotoxic/suppressor T-cells selectively reside within the epithelium of the normal bowel and some of them contain azurophilic granules, it could be suggested that our patient's lymphoma represents a malignant counterpart of these lymphocytes. Furthermore, the aggressive character of this T malignant lymphoma (T-ML) could be related to the expression of T-cell activation markers HLA-DR and Tac/CD25 and the proliferation-associated antigen Ki-67 on a high proportion of tumor cells. | en |
| heal.journalName | Am J Surg Pathol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
There are no files associated with this item.
This item is licensed under a Creative Commons License
