Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/24179
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dc.contributor.authorPapagoras, C.en
dc.contributor.authorDrosos, A. A.en
dc.date.accessioned2015-11-24T19:38:45Z-
dc.date.available2015-11-24T19:38:45Z-
dc.identifier.issn1744-7682-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24179-
dc.rightsDefault Licence-
dc.subjectAntirheumatic Agents/*therapeutic useen
dc.subjectArthritis, Rheumatoid/immunology/*therapyen
dc.subjectHumansen
dc.subjectImmunoconjugates/*therapeutic useen
dc.subject*Immunotherapyen
dc.subjectMeta-Analysis as Topicen
dc.subjectRandomized Controlled Trials as Topicen
dc.subjectTreatment Outcomeen
dc.titleAbatacept: a biologic immune modulator for rheumatoid arthritisen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1517/14712598.2011.592825-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21649536-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.1517/14712598.2011.592825-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2011-
heal.abstractINTRODUCTION: Abatacept is a biologic drug that belongs to the class of T-cell co-stimulation modulators and is used for the treatment of rheumatoid arthritis (RA). AREAS COVERED: This article covers major randomized clinical trials and meta-analyses concerning abatacept in the treatment of RA, as identified in a Pubmed search. Scientific meeting abstracts describing long-term extension data of the identified trials are also included. Efficacy outcomes and the safety profile are the focus of this evaluation. EXPERT OPINION: Abatacept in combination with methotrexate (MTX) or other synthetic disease-modifying anti-rheumatic drugs (DMARD) has been proven effective for the treatment of RA in different groups of patients: with early RA and no prior exposure to DMARD; with DMARD-resistant RA; and with RA not responding to TNF-alpha-blocking agents. Significant reductions of disease activity are achieved, with 1-year remission rates reaching up to 41% of DMARD-naive patients with early RA receiving a combination of abatacept plus MTX. Abatacept treatment has been shown to improve function and quality of life and to suppress radiographic progression. No major safety issues have emerged during clinical trials and long-term extensions. Therefore, abatacept is a drug with a favorable efficacy and safety profile, which may offer substantial benefits to RA patients.en
heal.journalNameExpert Opin Biol Theren
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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