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https://olympias.lib.uoi.gr/jspui/handle/123456789/24106Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kyriakides, Z. S. | en |
| dc.contributor.author | Kremastinos, D. T. | en |
| dc.contributor.author | Kolettis, T. M. | en |
| dc.contributor.author | Tasouli, A. | en |
| dc.contributor.author | Antoniadis, A. | en |
| dc.contributor.author | Webb, D. J. | en |
| dc.date.accessioned | 2015-11-24T19:38:04Z | - |
| dc.date.available | 2015-11-24T19:38:04Z | - |
| dc.identifier.issn | 1524-4539 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24106 | - |
| dc.rights | Default Licence | - |
| dc.subject | *Angioplasty, Balloon, Coronary | en |
| dc.subject | Antihypertensive Agents/*pharmacology | en |
| dc.subject | Blood Pressure/drug effects | en |
| dc.subject | Collateral Circulation/drug effects | en |
| dc.subject | Coronary Angiography | en |
| dc.subject | Coronary Vessels/drug effects | en |
| dc.subject | Electrocardiography/methods | en |
| dc.subject | Female | en |
| dc.subject | Heart Rate/drug effects | en |
| dc.subject | Humans | en |
| dc.subject | Infusions, Intra-Arterial | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Myocardial Ischemia/*metabolism/radiography/surgery | en |
| dc.subject | Pain Measurement/drug effects | en |
| dc.subject | Peptides, Cyclic/*pharmacology | en |
| dc.subject | Receptor, Endothelin A | en |
| dc.subject | Receptors, Endothelin/*antagonists & inhibitors/metabolism | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Acute endothelin-A receptor antagonism prevents normal reduction of myocardial ischemia on repeated balloon inflations during angioplasty | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11034942 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2000 | - |
| heal.abstract | BACKGROUND: Myocardial ischemia and reperfusion are associated with increased production of endothelin (ET)-1. METHODS AND RESULTS: We examined the effects of BQ-123, a selective ET(A) receptor antagonist, in 80 patients. All patients were randomly allocated to an intracoronary infusion of saline or BQ-123 (6 micromol/L over 20 minutes). The reference group consisted of 20 patients undergoing coronary angiography. BQ-123 produced a 10% (P:<0.005) increase in distal coronary artery diameter. The main study group consisted of 30 patients undergoing coronary angioplasty. All patients underwent a minimum of 3 balloon inflations (BIs). Surface and intracoronary electrocardiographic ST-segment shift as well as pain score were recorded at the end of each BI. BQ-123 or saline was given by intracoronary infusion between the second and the third BI in random allocation. In the saline group, intracoronary ST-elevation decreased from 1.26+/-0.55 mV during the first BI to 0.77+/-0.56 mV during the third BI (P:<0.05) and the surface ST elevation decreased from 0.20+/-0.15 to 0.10+/-0.07 mV (P:<0.05). In the BQ-123 group, the respective values were 1.22+/-0.48 mV and 1.13+/-0.62 mV (intracoronary) and 0.17+/-0.18 and 0.17+/-0.21 mV (surface) (both P:=NS). The decrease in pain score was significantly higher in the saline group (F:=5.97, P:=0.004). In 30 patients (collateral circulation group), the angioplasty protocol was repeated with the use of a pressure guide wire. BQ-123 produced a significant (F:=3.30, P:=0.04) decrease in coronary wedge pressure. CONCLUSIONS: Acute ET(A) receptor antagonism prevents the normal reduction of myocardial ischemia on repeated BIs during angioplasty. This may be explained by a "steal" effect through coronary collaterals. | en |
| heal.journalName | Circulation | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kolettis-2000-acute endothelin A.pdf | 261.39 kB | Adobe PDF | View/Open Request a copy |
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