Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/24088Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bourantas, K. L. | en |
| dc.contributor.author | Dalekos, G. N. | en |
| dc.contributor.author | Makis, A. | en |
| dc.contributor.author | Chaidos, A. | en |
| dc.contributor.author | Tsiara, S. | en |
| dc.contributor.author | Mavridis, A. | en |
| dc.date.accessioned | 2015-11-24T19:37:51Z | - |
| dc.date.available | 2015-11-24T19:37:51Z | - |
| dc.identifier.issn | 0902-4441 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24088 | - |
| dc.rights | Default Licence | - |
| dc.subject | Acute-Phase Proteins/*analysis/*metabolism | en |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Anemia, Sickle Cell/*blood/*metabolism | en |
| dc.subject | Child | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Interleukins/*blood/*metabolism | en |
| dc.subject | Male | en |
| dc.subject | Tumor Necrosis Factor-alpha/metabolism | en |
| dc.subject | beta 2-Microglobulin/metabolism | en |
| dc.subject | beta-Thalassemia/blood | en |
| dc.title | Acute phase proteins and interleukins in steady state sickle cell disease | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9688292 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1600-0609.1998.tb01060.x/asset/j.1600-0609.1998.tb01060.x.pdf?v=1&t=h0t6hbk5&s=672ff15f90f70e988b845c7317cda0f5bd1fb831 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1998 | - |
| heal.abstract | To identify a possible acute phase response during the steady state of sickle cell disease, we estimated the serum alterations of acute phase proteins, beta2-microglobulin (beta2M), kappa and lambda light chains, interleukins (ILs) and tumor necrosis factor-alpha (TNFalpha) in 21 patients. Increased concentrations of C-reactive protein (CRP) were found in 5 patients, alpha-1-acid-glycoprotein (AGP) in 3, alpha-1-antitrypsin (AAT) in 8, ceruloplasmin (CER) in 2, alpha-2-macroglobulin (AMG) in 14 and decreased haptoglobin (HPT) and transferrin (TFR) in 11 and 9, respectively. Increased beta2M was found in 10 patients and kappa and lambda light chains in 11. IL-1beta, IL-2, IL-4, IL-10 and TNFalpha were not detected in any of the patients. However, significantly increased values of IL-6 and sIL-2r were found. This study has demonstrated increased serum levels of some of the acute phase proteins in patients during the steady state of sickle cell disease. This may be a result of a subclinical vaso-occlusion which in turn leads to a covert inflammatory response. Cytokines, and in particular IL-6, produced after this response, seem to be responsible for the high levels of acute phase proteins in the steady state of this disease. | en |
| heal.journalName | Eur J Haematol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Bourantas-1998-Acute phase proteins.pdf | 550.01 kB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License
