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dc.contributor.authorBourantas, K. L.en
dc.contributor.authorDalekos, G. N.en
dc.contributor.authorMakis, A.en
dc.contributor.authorChaidos, A.en
dc.contributor.authorTsiara, S.en
dc.contributor.authorMavridis, A.en
dc.date.accessioned2015-11-24T19:37:51Z-
dc.date.available2015-11-24T19:37:51Z-
dc.identifier.issn0902-4441-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24088-
dc.rightsDefault Licence-
dc.subjectAcute-Phase Proteins/*analysis/*metabolismen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAnemia, Sickle Cell/*blood/*metabolismen
dc.subjectChilden
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInterleukins/*blood/*metabolismen
dc.subjectMaleen
dc.subjectTumor Necrosis Factor-alpha/metabolismen
dc.subjectbeta 2-Microglobulin/metabolismen
dc.subjectbeta-Thalassemia/blooden
dc.titleAcute phase proteins and interleukins in steady state sickle cell diseaseen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9688292-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1600-0609.1998.tb01060.x/asset/j.1600-0609.1998.tb01060.x.pdf?v=1&t=h0t6hbk5&s=672ff15f90f70e988b845c7317cda0f5bd1fb831-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1998-
heal.abstractTo identify a possible acute phase response during the steady state of sickle cell disease, we estimated the serum alterations of acute phase proteins, beta2-microglobulin (beta2M), kappa and lambda light chains, interleukins (ILs) and tumor necrosis factor-alpha (TNFalpha) in 21 patients. Increased concentrations of C-reactive protein (CRP) were found in 5 patients, alpha-1-acid-glycoprotein (AGP) in 3, alpha-1-antitrypsin (AAT) in 8, ceruloplasmin (CER) in 2, alpha-2-macroglobulin (AMG) in 14 and decreased haptoglobin (HPT) and transferrin (TFR) in 11 and 9, respectively. Increased beta2M was found in 10 patients and kappa and lambda light chains in 11. IL-1beta, IL-2, IL-4, IL-10 and TNFalpha were not detected in any of the patients. However, significantly increased values of IL-6 and sIL-2r were found. This study has demonstrated increased serum levels of some of the acute phase proteins in patients during the steady state of sickle cell disease. This may be a result of a subclinical vaso-occlusion which in turn leads to a covert inflammatory response. Cytokines, and in particular IL-6, produced after this response, seem to be responsible for the high levels of acute phase proteins in the steady state of this disease.en
heal.journalNameEur J Haematolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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