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https://olympias.lib.uoi.gr/jspui/handle/123456789/24049Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Gomez-Manzano, C. | en |
| dc.contributor.author | Fueyo, J. | en |
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.contributor.author | Steck, P. A. | en |
| dc.contributor.author | Roth, J. A. | en |
| dc.contributor.author | McDonnell, T. J. | en |
| dc.contributor.author | Steck, K. D. | en |
| dc.contributor.author | Levin, V. A. | en |
| dc.contributor.author | Yung, W. K. | en |
| dc.date.accessioned | 2015-11-24T19:37:34Z | - |
| dc.date.available | 2015-11-24T19:37:34Z | - |
| dc.identifier.issn | 0008-5472 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24049 | - |
| dc.rights | Default Licence | - |
| dc.subject | *Adenoviruses, Human | en |
| dc.subject | *Apoptosis | en |
| dc.subject | Blotting, Western | en |
| dc.subject | Cell Division | en |
| dc.subject | Cell Line | en |
| dc.subject | Flow Cytometry | en |
| dc.subject | Gene Expression | en |
| dc.subject | *Genes, p53 | en |
| dc.subject | Genetic Vectors | en |
| dc.subject | Glioma/genetics | en |
| dc.subject | Homozygote | en |
| dc.subject | Humans | en |
| dc.subject | Kinetics | en |
| dc.subject | Recombinant Proteins/biosynthesis | en |
| dc.subject | Time Factors | en |
| dc.subject | Transfection/*methods | en |
| dc.subject | Tumor Cells, Cultured | en |
| dc.subject | Tumor Suppressor Protein p53/*biosynthesis | en |
| dc.title | Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8630997 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1996 | - |
| heal.abstract | Wild-type p53 is involved in several aspects of cell cycle control and suppression of transformation, inducing either apoptosis or G1 block in cell cycle progression. Using a recombinant adenovirus containing the wild-type p53 cDNA, the biological effects of the newly expressed wild-type p53 protein were examined in six human glioma cell lines. Three cell lines (U-251 MG, U-373 MG, and A-172) expressed endogenous mutant p53, and the other three (U-87 MG, EFC-2, and D54 MG) expressed wild-type p53. The restoration of normal p53-encoded protein in the mutant cell lines induced apoptosis as assessed by morphological studies using nuclear staining, electron microscopy, and flow cytometric assays. In wild-type p53 cell lines, however, the overexpression of wild-type p53 did not result in apoptosis but inhibited cellular proliferation rather drastically and modified the neoplastic phenotype. Differential effects suggest two pathways for glioma oncogenesis and a possible therapeutic strategy. | en |
| heal.journalName | Cancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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