Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/23999Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kavvoura, F. K. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:37:11Z | - |
| dc.date.available | 2015-11-24T19:37:11Z | - |
| dc.identifier.issn | 0340-6717 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23999 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Asian Continental Ancestry Group | en |
| dc.subject | Basic Helix-Loop-Helix Transcription Factors | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Continental Population Groups | en |
| dc.subject | DNA-Binding Proteins/*genetics | en |
| dc.subject | Diabetes Mellitus, Type 1/ethnology/*genetics | en |
| dc.subject | Diabetes Mellitus, Type 2/ethnology/*genetics | en |
| dc.subject | European Continental Ancestry Group | en |
| dc.subject | Female | en |
| dc.subject | *Genetic Predisposition to Disease | en |
| dc.subject | Genotype | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Odds Ratio | en |
| dc.subject | *Polymorphism, Genetic | en |
| dc.subject | Risk Factors | en |
| dc.subject | Trans-Activators/*genetics | en |
| dc.title | Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1007/s00439-004-1224-5 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15592940 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/0kgph7enwwvwg06p/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2005 | - |
| heal.abstract | A meta-analysis assessed whether the Ala45Thr polymorphism of the neurogenic differentiation 1 (NEUROD1) gene is associated with increased risk of diabetes mellitus type 1 (T1D) or type 2 (T2D). Fourteen case-control studies were analyzed, including genotype data on 3,057 patients with diabetes (T1D n=1,213, T2D n=1,844) and 2,446 controls. Overall and race-specific summary odds ratios (ORs) were obtained with fixed and random effects models. The Thr allele did not significantly increase the overall risk for T1D (OR 1.27 [0.94-1.71], P=0.12) or T2D (OR 1.07 [0.90-1.28], P=0.46). The Thr allele conferred increased susceptibility in subjects of Asian racial descent to T1D (OR 1.88 [1.10-3.21], P=0.020), but not to T2D (OR 1.08 [0.74-1.56], P=0.70). There was no association in subjects of European descent (OR 0.97 [0.76-1.23], P=0.80 for T1D; OR 1.03 [0.88-1.21], P=0.68 for T2D). Larger studies seemed to show more conservative estimates for the association with T1D (P=0.083). The Ala45Thr polymorphism of the NEUROD1 gene has no effect on susceptibility to T2D. It may however be a risk factor for susceptibility to T1D, in particular for subjects of Asian descent, although bias cannot be totally excluded. | en |
| heal.journalName | Hum Genet | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kavvoura-2005-Ala45Thr polymorphis.pdf | 238.62 kB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License
