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https://olympias.lib.uoi.gr/jspui/handle/123456789/23857Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Murphy, C. | en |
| dc.contributor.author | Fotsis, T. | en |
| dc.contributor.author | Pantzar, P. | en |
| dc.contributor.author | Adlercreutz, H. | en |
| dc.contributor.author | Martin, F. | en |
| dc.date.accessioned | 2015-11-24T19:36:20Z | - |
| dc.date.available | 2015-11-24T19:36:20Z | - |
| dc.identifier.issn | 0022-4731 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23857 | - |
| dc.rights | Default Licence | - |
| dc.subject | Breast Neoplasms/*analysis | en |
| dc.subject | Cell Nucleus/analysis | en |
| dc.subject | Cytosol/analysis | en |
| dc.subject | Female | en |
| dc.subject | Gas Chromatography-Mass Spectrometry | en |
| dc.subject | Humans | en |
| dc.subject | Potassium Chloride/pharmacology | en |
| dc.subject | Tamoxifen/*analogs & derivatives/*analysis | en |
| dc.title | Analysis of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen levels in cytosol and KCl-nuclear extracts of breast tumours from tamoxifen treated patients by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM) | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/3695512 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/0022473187903876/1-s2.0-0022473187903876-main.pdf?_tid=ff0e97817b7e3db00566f5de99ee93a8&acdnat=1332753059_80f19587c20ad715906b691cd0d81419 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1987 | - |
| heal.abstract | Tamoxifen, 4-hydroxytamoxifen and desmethyltamoxifen levels were measured in cytosolic and 0.5 M KCl extracted nuclear fractions from a small series of breast tumours from tamoxifen treated patients by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). Tamoxifen and desmethyltamoxifen were the most abundant metabolites. There was a small increment in the relative abundance of 4-hydroxytamoxifen in the nuclear extract over cytosol relative to both tamoxifen and desmethyltamoxifen. Further, there was a selective retention of tamoxifen relative to desmethyltamoxifen in the nuclear extract relative to the cytosol. It is concluded that all three compounds could potentially contribute to estrogen receptor mediated antiestrogenic effects in this target tissue. | en |
| heal.journalName | J Steroid Biochem | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Murphy-1987-Analysis of tamoxife.pdf | 908.35 kB | Adobe PDF | View/Open Request a copy |
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