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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Avdikos, A. | en |
| dc.contributor.author | Karkabounas, S. | en |
| dc.contributor.author | Metsios, A. | en |
| dc.contributor.author | Kostoula, O. | en |
| dc.contributor.author | Havelas, K. | en |
| dc.contributor.author | Binolis, J. | en |
| dc.contributor.author | Verginadis, I. | en |
| dc.contributor.author | Hatziaivazis, G. | en |
| dc.contributor.author | Simos, I. | en |
| dc.contributor.author | Evangelou, A. | en |
| dc.date.accessioned | 2015-11-24T19:36:05Z | - |
| dc.date.available | 2015-11-24T19:36:05Z | - |
| dc.identifier.issn | 1790-5427 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23805 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Antineoplastic Agents/*therapeutic use | en |
| dc.subject | Aorta/metabolism | en |
| dc.subject | Disease Models, Animal | en |
| dc.subject | *Electromagnetic Fields | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Leiomyosarcoma/*radiotherapy | en |
| dc.subject | Myocytes, Smooth Muscle/metabolism | en |
| dc.subject | Neoplasms/metabolism | en |
| dc.subject | Radio Waves | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Time Factors | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Anticancer effects on leiomyosarcoma-bearing Wistar rats after electromagnetic radiation of resonant radiofrequencies | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17684584 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2007 | - |
| heal.abstract | In the present study, the effects of a resonant low intensity static electromagnetic field (EMF), causing no thermal effects, on Wistar rats have been investigated. Sarcoma cell lines were isolated from leiomyosarcoma tumors induced in Wistar rats by the subcutaneous (s.c) injection of 3,4-benzopyrene. Furthermore, smooth muscle cells (SMC) were isolated from the aorta of Wistar rats and cultivated. Either leiomyosarcoma cells (LSC) or SMC were used to record a number of characteristic resonant radiofrequencies, in order to determine the specific electromagnetic fingerprint spectrum for each cell line. These spectra were used to compose an appropriate algorithm, which transforms the recorded radiofrequencies to emitted ones. The isolated LSC were cultured and then exposed to a resonant low intensity radiofrequency EMF (RF-EMF), at frequencies between 10 kHz to 120 kHz of the radiowave spectrum. The exposure lasted 45 consecutive minutes daily, for two consecutive days. Three months old female Wistar rats were inoculated with exposed and non-exposed to EMF LSC (4 x 10(6) LCS for animal). Inoculated with non-exposed to EMF cells animals were then randomly separated into three Groups. The first Group was sham exposed to the resonant EMF (control Group-CG), the second Group after the inoculation of LSC and appearance of a palpable tumor mass, was exposed to a non-resonant EMF radiation pattern, for 5 h per day till death of all animals (experimental control Group-ECG). The third Group of animals after inoculation of LSC and the appearance of a palpable tumor mass, was exposed to the resonant EMF radiation for 5 h per day, for a maximum of 60 days (experimental Group-I, EG-I). A fourth Group of animals was inoculated with LSC exposed to EMF irradiation and were not further exposed to irradiation (experimental Group-II, EG-II). Tumor induction was 100% in all Groups studied and all tumors were histologically identified as leiomyosarcomas. In the case of the EG-I, a number of tumors were completely regretted (final tumor induction: 66%). Both Groups of animals inoculated with exposed or non-exposed to the EMF LSC, (EG-I and EG-II, respectively) demonstrated a significant prolongation of the survival time and a lower tumor growth rate, in comparison to the control Group (CG) and the experimental control Group (ECG). However, the survival time of EG-I animals was found to be significantly longer and tumor growth rate significantly lower compared to EG-II animals. In conclusion, our results indicate a specific anticancer effect of resonant EMF irradiation. These results may possibly be attributed to (a) the duration of exposure of LSC and (b) the exposure of the entire animal to this irradiation. | en |
| heal.journalName | Hell J Nucl Med | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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