Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23755
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dc.contributor.authorKostapanos, M. S.en
dc.contributor.authorChristogiannis, L. G.en
dc.contributor.authorBika, E.en
dc.contributor.authorBairaktari, E. T.en
dc.contributor.authorGoudevenos, J. A.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorMilionis, H. J.en
dc.date.accessioned2015-11-24T19:35:49Z-
dc.date.available2015-11-24T19:35:49Z-
dc.identifier.issn1532-8511-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23755-
dc.rightsDefault Licence-
dc.subjectAge Factorsen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectApolipoprotein A-I/*blooden
dc.subjectApolipoproteins B/*blooden
dc.subjectBiological Markers/blooden
dc.subjectBrain Ischemia/*blood/etiologyen
dc.subjectCase-Control Studiesen
dc.subjectChi-Square Distributionen
dc.subjectCross-Sectional Studiesen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectLogistic Modelsen
dc.subjectMaleen
dc.subjectOdds Ratioen
dc.subjectPredictive Value of Testsen
dc.subjectPrognosisen
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectStroke/*blood/etiologyen
dc.subjectUp-Regulationen
dc.titleApolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjectsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.jstrokecerebrovasdis.2009.09.010-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20538481-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1052305709001992/1-s2.0-S1052305709001992-main.pdf?_tid=905d9dd2b3fd2f5241b348ce0be1482a&acdnat=1333532660_e52d0c5970307155ddaa25950c998a41-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractAmong traditional cardiovascular risk factors, apolipoprotein (apo)B/apoA1 ratio is considered to have the strongest predictive value for ischemic stroke. Nevertheless, there are imsufficient data to support this ratio as an independent risk predictor of ischemic stroke in elderly individuals. In this case-control study, we evaluated apoB/apoA1 ratio as a predictor of ischemic stroke in a cohort of elderly subjects. A total of 163 patients aged>70 years (88 men) admitted due to a first-ever acute ischemic/nonembolic stroke and 166 volunteers (87 men) with no history of cardiovascular disease were included. The association between apoB/apoA1 ratio and stroke was determined by multivariate logistic regression modeling after adjusting for potential confounding factors, including lipid parameters. Stroke patients exhibited a higher apoB/apoA1 ratio than controls (1.04+/-0.33 vs 0.86+/-0.22; P<.001). In univariate analysis, crude odds ratio (OR) for apoB/apoA1 ratio was 1.27 per 0.1 increase (95% confidence interval [CI]=1.15-1.39; P<.001). Compared with subjects with an apoB/apoA1 ratio in the lowest quartile, those within the highest quartile had a 6.3-fold increase in the odds of suffering an ischemic stroke (95% CI=3.17-12.48; P<.001). This association remained significant after controlling for potential confounders, including sex, age, smoking status, body mass index, waist circumference, glucose and insulin levels, the presence of hypertension and diabetes mellitus, and lipid profile parameters (adjusted OR=3.02; 95% CI=1.16-7.83; P=.02). Our findings support elevated apoB/apoA1 ratio as an independent predictor of ischemic stroke in individuals over age 70.en
heal.journalNameJ Stroke Cerebrovasc Disen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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