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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23738
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dc.contributor.authorMiaczynska, M.en
dc.contributor.authorChristoforidis, S.en
dc.contributor.authorGiner, A.en
dc.contributor.authorShevchenko, A.en
dc.contributor.authorUttenweiler-Joseph, S.en
dc.contributor.authorHabermann, B.en
dc.contributor.authorWilm, M.en
dc.contributor.authorParton, R. G.en
dc.contributor.authorZerial, M.en
dc.date.accessioned2015-11-24T19:35:45Z-
dc.date.available2015-11-24T19:35:45Z-
dc.identifier.issn0092-8674-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23738-
dc.rightsDefault Licence-
dc.subjectBinding Sites/geneticsen
dc.subjectCarrier Proteins/genetics/*metabolismen
dc.subjectCell Compartmentation/geneticsen
dc.subjectCell Division/geneticsen
dc.subjectCell Membrane/*metabolism/ultrastructureen
dc.subjectCell Nucleus/*metabolism/ultrastructureen
dc.subjectEndocytosis/*physiologyen
dc.subjectEndosomes/*metabolism/ultrastructureen
dc.subjectGuanosine Triphosphate/metabolismen
dc.subjectHeLa Cellsen
dc.subjectHistone Deacetylases/geneticsen
dc.subjectHumansen
dc.subjectMi-2 Nucleosome Remodeling and Deacetylase Complexen
dc.subjectMicroscopy, Electronen
dc.subjectProtein Binding/geneticsen
dc.subjectProtein Transport/geneticsen
dc.subject*Protein-Serine-Threonine Kinasesen
dc.subject*Proto-Oncogene Proteinsen
dc.subjectProto-Oncogene Proteins c-akten
dc.subjectSignal Transduction/geneticsen
dc.subjectrab5 GTP-Binding Proteins/genetics/*metabolismen
dc.titleAPPL proteins link Rab5 to nuclear signal transduction via an endosomal compartmenten
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15016378-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0092867404001175/1-s2.0-S0092867404001175-main.pdf?_tid=9c86b43e7a50ae8685bf2bf31f54caab&acdnat=1333009049_092aba754f44c8bcbe63ced609c3cc09-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2004-
heal.abstractSignals generated in response to extracellular stimuli at the plasma membrane are transmitted through cytoplasmic transduction cascades to the nucleus. We report the identification of a pathway directly linking the small GTPase Rab5, a key regulator of endocytosis, to signal transduction and mitogenesis. This pathway operates via APPL1 and APPL2, two Rab5 effectors, which reside on a subpopulation of endosomes. In response to extracellular stimuli such as EGF and oxidative stress, APPL1 translocates from the membranes to the nucleus where it interacts with the nucleosome remodeling and histone deacetylase multiprotein complex NuRD/MeCP1, an established regulator of chromatin structure and gene expression. Both APPL1 and APPL2 are essential for cell proliferation and their function requires Rab5 binding. Our findings identify an endosomal compartment bearing Rab5 and APPL proteins as an intermediate in signaling between the plasma membrane and the nucleus.en
heal.journalNameCellen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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