Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/23722
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gong, H. | en |
dc.contributor.author | Zolzer, F. | en |
dc.contributor.author | von Recklinghausen, G. | en |
dc.contributor.author | Rossler, J. | en |
dc.contributor.author | Breit, S. | en |
dc.contributor.author | Havers, W. | en |
dc.contributor.author | Fotsis, T. | en |
dc.contributor.author | Schweigerer, L. | en |
dc.date.accessioned | 2015-11-24T19:35:39Z | - |
dc.date.available | 2015-11-24T19:35:39Z | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23722 | - |
dc.rights | Default Licence | - |
dc.subject | Apoptosis/*drug effects | en |
dc.subject | Arginine/metabolism | en |
dc.subject | Cell Cycle/*drug effects | en |
dc.subject | Cell Division/drug effects | en |
dc.subject | Cell Nucleus/drug effects/metabolism | en |
dc.subject | Cells, Cultured | en |
dc.subject | DNA Fragmentation/drug effects | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Endothelium, Vascular/cytology/drug effects | en |
dc.subject | Humans | en |
dc.subject | Hydrolases/*pharmacology | en |
dc.subject | Mycoplasma/enzymology | en |
dc.subject | Signal Transduction/drug effects | en |
dc.subject | Tumor Cells, Cultured | en |
dc.title | Arginine deiminase inhibits cell proliferation by arresting cell cycle and inducing apoptosis | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | 10.1006/bbrc.1999.1004 | - |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10405315 | - |
heal.identifier.secondary | http://ac.els-cdn.com/S0006291X99910045/1-s2.0-S0006291X99910045-main.pdf?_tid=dc0c73c6d2f1534b37a30a6e6a1bbc2f&acdnat=1332752222_81de9796e5217e916a1846b1cb1bafe7 | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
heal.publicationDate | 1999 | - |
heal.abstract | We have previously demonstrated that arginine deiminase inhibits the proliferation of vascular endothelial cells, but the mechanisms leading to growth inhibition have remained unclear. We report here that low concentrations of arginine deiminase purified from Mycoplasma arginini inhibit proliferation of various cultured cells by arresting the cell cycle in G(1) and/or S phase with higher arginine deiminase concentrations leading to subsequent apoptosis. Our results demonstrate that arginine deiminase inhibits cell proliferation not only by depletion of arginine, but also by mechanisms involving the cell cycle and death signals. | en |
heal.journalName | Biochem Biophys Res Commun | en |
heal.journalType | peer-reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Gong-1999-Arginine deiminase i.pdf | 93.87 kB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License