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dc.contributor.authorLazaros, L. A.en
dc.contributor.authorHatzi, E. G.en
dc.contributor.authorXita, N. V.en
dc.contributor.authorMakrydimas, G. V.en
dc.contributor.authorKaponis, A. I.en
dc.contributor.authorTakenaka, A.en
dc.contributor.authorKosmas, I. P.en
dc.contributor.authorSofikitis, N. V.en
dc.contributor.authorStefos, T. I.en
dc.contributor.authorZikopoulos, K. A.en
dc.contributor.authorGeorgiou, I. A.en
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dc.titleAromatase (CYP19) gene variants influence ovarian response to standard gonadotrophin stimulationen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractPURPOSE: The association of cytochrome P450 aromatase gene CYP19(TTTA) ( n ) polymorphism with ovarian response to FSH stimulation was explored. METHODS: Three hundred women undergoing medically assisted reproduction and 300 women with at least one spontaneous pregnancy participated in the study. CYP19(TTTA) ( n ) polymorphism was genotyped, while serum hormones were determined. During oocyte retrieval, the follicular size, the follicle and oocyte numbers were recorded. RESULTS: Six CYP19(TTTA) ( n ) alleles with 7 to 12 repeats were revealed. Women homozygous for long CYP19(TTTA) ( n ) alleles presented with lower serum FSH levels at the third day of the menstrual cycle (p < 0.001) and higher large follicle numbers (p < 0.01), compared to women homozygous for short CYP19(TTTA) ( n ) alleles. The CYP19(TTTA) ( 7 ) allele was associated with higher serum FSH levels (p < 0.003), with lower total follicle (p < 0.02) and large follicle numbers (p < 0.03), while CYP19(TTTA) ( 7 ) allele-carriers presented more frequently with small follicles than CYP19(TTTA) ( 7 ) allele-non carriers (p < 0.01). CONCLUSIONS: CYP19 genetic variants were associated with ovarian reserve and response to standard gonadotrophin stimulation of women undergoing in vitro fertilization.en
heal.journalNameJ Assist Reprod Geneten
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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