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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Liu, T. | en |
| dc.contributor.author | Korantzopoulos, P. | en |
| dc.contributor.author | Xu, G. | en |
| dc.contributor.author | Shehata, M. | en |
| dc.contributor.author | Li, D. | en |
| dc.contributor.author | Wang, X. | en |
| dc.contributor.author | Li, G. | en |
| dc.date.accessioned | 2015-11-24T19:35:04Z | - |
| dc.date.available | 2015-11-24T19:35:04Z | - |
| dc.identifier.issn | 1532-2092 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23675 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Atrial Fibrillation/epidemiology/*genetics/physiopathology | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | INDEL Mutation/*genetics | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Peptidyl-Dipeptidase A/*genetics | en |
| dc.subject | Polymorphism, Genetic/genetics | en |
| dc.subject | Renin-Angiotensin System/physiology | en |
| dc.subject | Risk Factors | en |
| dc.title | Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysis | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1093/europace/euq407 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21076147 | - |
| heal.identifier.secondary | http://europace.oxfordjournals.org/content/13/3/346.full.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2011 | - |
| heal.abstract | AIMS: Recent observations have raised concerns regarding the activation of the renin-angiotensin system and the development of atrial fibrillation (AF). Some initial studies indicated an association between an angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism and AF, however, the results have been inconsistent. Our aim was to perform a meta-analysis of relevant studies to assess the validity of this association. METHODS AND RESULTS: PubMed, Cochrane clinical trials database, and EMBASE were searched through July 2009, and a manual search was also performed. Of the 68 initially identified studies, 18 case-control studies with 7577 patients were finally analysed. No statistically significant associations were found between the ACE I/D polymorphism and AF risk in the genetic additive model and dominant model, whereas a significant association was observed in the recessive model. A significant heterogeneity between individual studies was evident in all three models. Subgroup analyses showed a strong association between the ACE I/D polymorphism and hypertensive AF without significant heterogeneity. CONCLUSION: Our meta-analysis suggests that there is insufficient evidence to demonstrate an association between ACE I/D polymorphism and AF risk. However, there seems to be a significant association between ACE I/D gene polymorphic variation and AF in patients with hypertension. Additional studies are warranted to further explore this association in ethnically diverse populations and varied cardiovascular substrates. | en |
| heal.journalName | Europace | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Liu-2011-Association between.pdf | 527.43 kB | Adobe PDF | View/Open Request a copy |
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