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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Panoulas, V. F. | en |
| dc.contributor.author | Stavropoulos-Kalinoglou, A. | en |
| dc.contributor.author | Metsios, G. S. | en |
| dc.contributor.author | Smith, J. P. | en |
| dc.contributor.author | Milionis, H. J. | en |
| dc.contributor.author | Douglas, K. M. | en |
| dc.contributor.author | Nightingale, P. | en |
| dc.contributor.author | Kitas, G. D. | en |
| dc.date.accessioned | 2015-11-24T19:34:50Z | - |
| dc.date.available | 2015-11-24T19:34:50Z | - |
| dc.identifier.issn | 1879-1484 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23656 | - |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Arthritis, Rheumatoid/complications/epidemiology/*genetics/immunology | en |
| dc.subject | Cardiovascular Diseases/epidemiology/*genetics/immunology | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Female | en |
| dc.subject | Gene Frequency | en |
| dc.subject | Genetic Predisposition to Disease | en |
| dc.subject | Humans | en |
| dc.subject | Interleukin-6/blood/*genetics | en |
| dc.subject | Logistic Models | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Obesity/*complications/epidemiology | en |
| dc.subject | Odds Ratio | en |
| dc.subject | *Polymorphism, Genetic | en |
| dc.subject | Prevalence | en |
| dc.subject | Risk Assessment | en |
| dc.subject | Risk Factors | en |
| dc.subject | Smoking/*adverse effects/epidemiology | en |
| dc.title | Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: the role of obesity and smoking | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.atherosclerosis.2008.08.036 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18848327 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0021915008006217/1-s2.0-S0021915008006217-main.pdf?_tid=d62c0bb5aea043ed117862f657ef3f52&acdnat=1333952825_6b2462412af194ca840b762e39f57345 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2009 | - |
| heal.abstract | BACKGROUND: Cardiovascular morbidity and mortality are increased in rheumatoid arthritis (RA). Interleukin-6 (IL-6) is high in RA and, together with smoking and obesity, an important contributor to the development of cardiovascular disease (CVD). The present study examined the potential association of IL-6-174 G/C polymorphism, together with obesity and smoking, with the presence of CVD in RA patients. METHODS AND RESULTS: DNA samples were collected from 383 RA patients (who also had extensive clinical and laboratory evaluations). IL-6-174 G/C was identified using real time PCR and melting curve analysis. Serum IL-6 levels were measured in a subgroup of 135 RA patients to examine the functionality of the polymorphism. Carriers of the IL6-174C-allele demonstrated increased prevalence of CVD (26.2% vs. 17.0%, p=0.041). There was a significant association with CVD, even after adjustment for traditional CVD risk factors (OR=1.92, 95%CI: 1.03 to 3.58, p=0.041). IL-6 levels were significantly increased in C-allele carriers [14.02 (3.21-38.81) vs. 4.48 (2.25-16.5), p=0.028]. No significant interactions were observed between adiposity and IL6-174G/C genotypes. There was only a trend for an interaction between ever smoking and IL6 C-allele carriers on CVD. CONCLUSION: The IL-6-174C-allele may associate with CVD in RA patients and possibly exerts its effect via increased inflammation. This finding, if confirmed in future studies, may be used as a part of a genetic screening tool for RA patients at high CVD risk. | en |
| heal.journalName | Atherosclerosis | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Panoulas-2009-Association of inter.pdf | 154.59 kB | Adobe PDF | View/Open Request a copy |
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