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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lazaros, L. A. | en |
| dc.contributor.author | Xita, N. V. | en |
| dc.contributor.author | Chatzikyriakidou, A. L. | en |
| dc.contributor.author | Kaponis, A. I. | en |
| dc.contributor.author | Grigoriadis, N. G. | en |
| dc.contributor.author | Hatzi, E. G. | en |
| dc.contributor.author | Grigoriadis, I. G. | en |
| dc.contributor.author | Sofikitis, N. V. | en |
| dc.contributor.author | Zikopoulos, K. A. | en |
| dc.contributor.author | Georgiou, I. A. | en |
| dc.date.accessioned | 2015-11-24T19:34:30Z | - |
| dc.date.available | 2015-11-24T19:34:30Z | - |
| dc.identifier.issn | 1939-4640 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23629 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Base Sequence | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | DNA Primers | en |
| dc.subject | Humans | en |
| dc.subject | Infertility, Male/genetics | en |
| dc.subject | Male | en |
| dc.subject | Polymerase Chain Reaction | en |
| dc.subject | *Polymorphism, Genetic | en |
| dc.subject | Receptors, Tumor Necrosis Factor, Type I/*genetics | en |
| dc.subject | Receptors, Tumor Necrosis Factor, Type II/*genetics | en |
| dc.subject | *Sperm Count | en |
| dc.subject | Sperm Motility/*genetics | en |
| dc.subject | Tumor Necrosis Factor-alpha/*genetics | en |
| dc.title | Association of TNFalpha, TNFR1, and TNFR2 polymorphisms with sperm concentration and motility | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.2164/jandrol.110.011486 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21350240 | - |
| heal.identifier.secondary | http://www.andrologyjournal.org/cgi/content/abstract/33/1/74 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2012 | - |
| heal.abstract | Tumor necrosis factor alpha (TNFalpha) is a multifunctional cytokine that regulates various cellular processes related to spermatogenesis. Two types of cell receptors, TNFR1 and TNFR2, mediate TNFalpha activity. In the present study, we sought to explore the association of TNFalpha -857C-->T, TNFR1 36A-->G, and TNFR2 676T-->G polymorphisms with sperm concentration and motility. Two hundred ninety men were examined during infertility investigation; of those, 170 men were normozoospermic and 120 were oligospermic. Polymerase chain reaction analysis revealed significant differences in genotype distribution of the TNFR1 36A-->G polymorphism between normozoospermic and oligospermic men. Men with oligozoospermia presented TNFR1 36A/A genotypes less frequently than normozoospermic men (P < .001). The presence of the TNFR1 36G allele was significantly increased in oligospermic men (P < .001). Furthermore, the presence of the TNFR1 36G allele was associated with lower sperm concentration in normozoospermic men (P < .03) and in the total study population (P < .001), and with lower sperm motility in normozoospermic men (P < .007) and in the total study population (P < .001). No significant associations were found between TNFalpha -857C-->T and TNFR2 676T-->G polymorphisms and semen quality. The TNFR1 36A allele is associated with increased sperm concentration and motility in our series, supporting the significance of TNFR1 gene in semen quality. | en |
| heal.journalName | J Androl | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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