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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23626
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dc.contributor.authorTsianos, G. I.en
dc.contributor.authorEvangelou, E.en
dc.contributor.authorBoot, A.en
dc.contributor.authorZillikens, M. C.en
dc.contributor.authorvan Meurs, J. B.en
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorIoannidis, J. P.en
dc.date.accessioned2015-11-24T19:34:29Z-
dc.date.available2015-11-24T19:34:29Z-
dc.identifier.issn1522-1601-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23626-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectBayes Theoremen
dc.subjectCohort Studiesen
dc.subjectEnergy Metabolism/*geneticsen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectGenetic Association Studiesen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectLinear Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMuscle Proteins/*genetics/metabolismen
dc.subjectMuscle, Skeletal/*metabolismen
dc.subjectOdds Ratioen
dc.subjectPhenotypeen
dc.subjectPhysical Endurance/*geneticsen
dc.subject*Polymorphism, Single Nucleotideen
dc.subjectReceptor, Bradykinin B2/geneticsen
dc.subjectReceptors, Adrenergic, beta-2/geneticsen
dc.subject*Runningen
dc.subjectTask Performance and Analysisen
dc.subjectYoung Adulten
dc.titleAssociations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runnersen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1152/japplphysiol.00780.2009-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20044476-
heal.identifier.secondaryhttp://jap.physiology.org/content/108/3/567.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractAthletic endurance performance is probably partly under genetic control, but genetic association studies have yielded inconclusive results. The objective of the present study was to evaluate the association of polymorphisms in eight muscle- or metabolism-related genes with endurance performance in participants of the Olympus Marathon running race. We recruited 438 athletes who participated in the 2007 and 2008 annual running events of the Olympus Marathon: a 43.8-km race with an ascent from sea level to 2,690-m altitude and then a descent to 300 m. Phenotypes of interest were the competitive event time at the specific Olympus Marathon where the athlete was enrolled, the fastest reported timing ever achieved in an Olympus Marathon, and how many kilometers per week the athlete ran during the previous year. Eleven polymorphisms in alpha(3)-actinin (ACTN3), AMP deaminase-1 (AMPD1), bradykinin B(2) receptor (BDKRB2), beta(2)-adrenergic receptor (ADRB2), peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 alpha (PPARGC1A), PPAR-alpha (PPARA), PPAR-delta (PPARD), and apoliprotein E (APOE) were evaluated. Hardy-Weinberg equilibrium testing on the overall cohort of male athletes showed a significant deviation for BDKRB2 rs1799722 (P = 0.018; P = 0.006 when limited to 316 habitual male runners) with an excess of the TT genotype. Across all athletes, no associations showed nominal statistical significance for any of the three phenotypes, and the same was true when analyses were limited to men (n = 417). When limited to 316 male athletes who identified running as their preferred sport, ADRB2 rs1042713 had nominally significant associations with faster times for the minor (A) allele for the fastest time ever (P = 0.01). The direction of effect was identical as previously postulated only for BDKRB2 rs1799722 and ADRB2 rs1042713, indicating consistency. BDKRB2 rs1799722 and ADRB2 rs1042713 have some support for being implicated in endurance performance among habitual runners and require further investigation.en
heal.journalNameJ Appl Physiolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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