Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23581
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dc.contributor.authorKalantaridou, S. N.en
dc.contributor.authorNelson, L. M.en
dc.date.accessioned2015-11-24T19:33:54Z-
dc.date.available2015-11-24T19:33:54Z-
dc.identifier.issn0098-8421-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23581-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAutoimmune Diseases/immunology/*physiopathologyen
dc.subjectDisease Models, Animalen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectOophoritis/etiology/*immunology/physiopathologyen
dc.subjectOrgan Specificityen
dc.subjectPrimary Ovarian Insufficiency/*immunology/physiopathologyen
dc.subjectT-Lymphocytes, Helper-Induceren
dc.subjectThymectomy/*adverse effectsen
dc.titleAutoimmune premature ovarian failure: of mice and womenen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9458620-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1998-
heal.abstractAutoimmunity is a well-established mechanism of premature ovarian failure and may be the dominant cause of reversible premature ovarian failure. Because of its strong analogy with the human disease, murine experimental post-thymectomy autoimmune oophoritis may provide insight into the pathogenesis of autoimmune premature ovarian failure in women and might open new avenues to specific diagnostic and therapeutic methods. We reviewed the literature on murine experimental post-thymectomy autoimmune oophoritis in order to compare and contrast it with human autoimmune premature ovarian failure, to which it is similar in several ways. The histologic distribution of the ovarian lymphocytic infiltration is similar, and both have reduced natural killer cell activity. Susceptibility appears to be associated with genes outside the major histocompatibility complex in both the mouse and the human. Finally, the mouse model disorder is associated with a persistent neonatal-like Th2 response, which suggests possible similarities with autoimmune polyglandular failure type 1 in humans. In this condition autoimmunity develops despite an impaired cellular immune response.en
heal.journalNameJ Am Med Womens Assocen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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