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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Goussia, A. C. | en |
| dc.contributor.author | Ioachim, E. | en |
| dc.contributor.author | Agnantis, N. J. | en |
| dc.contributor.author | Mahera, M. | en |
| dc.contributor.author | Tsianos, E. V. | en |
| dc.date.accessioned | 2015-11-24T19:33:20Z | - |
| dc.date.available | 2015-11-24T19:33:20Z | - |
| dc.identifier.issn | 0213-3911 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23526 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adenocarcinoma/classification/*metabolism/pathology | en |
| dc.subject | Adenoma/classification/*metabolism/pathology | en |
| dc.subject | Cell Division | en |
| dc.subject | Colorectal Neoplasms/classification/*metabolism/pathology | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Ki-67 Antigen/*biosynthesis | en |
| dc.subject | Male | en |
| dc.subject | *Nuclear Proteins | en |
| dc.subject | Proliferating Cell Nuclear Antigen/*biosynthesis | en |
| dc.subject | Proto-Oncogene Proteins/*biosynthesis | en |
| dc.subject | Proto-Oncogene Proteins c-bcl-2/*biosynthesis | en |
| dc.subject | Proto-Oncogene Proteins c-mdm2 | en |
| dc.subject | Retinoblastoma Protein/*biosynthesis | en |
| dc.subject | Tumor Suppressor Protein p53/*biosynthesis | en |
| dc.title | Bcl-2 expression in colorectal tumours. Correlation with p53, mdm-2, Rb proteins and proliferation indices | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10963109 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2000 | - |
| heal.abstract | Immunostaining for bcl-2 protein was performed in 27 colorectal adenomas and 108 colorectal adenocarcinomas. The aim of the study was to determine bcl-2 expression in correlation with p53, mdm-2 and Rb expression, with proliferation indices (Ki-67-LI, PCNA-LI) as well as with conventional clinicopathological variables. A higher proportion of adenomas (30.8%) than carcinomas (16.7%) expressed bcl-2 and conversely, a lower proportion of adenomas (7.4%) than carcinomas expressed p53 (57.1%), the difference being statistically significant (p<0.0001). No correlation of bcl-2 expression with p53 expression (parallel or inverse) as well as with the other parameters studied was observed in any tumour. The bcl-2+/p53- subgroup of cancers showed a trend for correlation with negative lymph node status. Our data suggest, that bcl-2 expression may be involved in the early phase of colorectal carcinogenesis regardless of p53 status, while p53 function may be involved in a late stage of the adenoma-carcinoma sequence. P53 is apparently not involved in the regulation of apoptosis in the colorectal neoplasias or perhaps bcl-2 expression, as an early event in colorectal tumours, may occur before changes of p53 take place. Tumours with bcl-2+/p53- immunophenotype are frequently associated with negative lymph node status and seem to have a less aggressive behavior. | en |
| heal.journalName | Histol Histopathol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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