Blood pressure loci identified with a gene-centric array

Johnson, T.; Gaunt, T. R.; Newhouse, S. J.; Padmanabhan, S.; Tomaszewski, M.; Kumari, M.; Morris, R. W.; Tzoulaki, I.; O'Brien, E. T.; Poulter, N. R.; Sever, P.; Shields, D. C.; Thom, S.; Wannamethee, S. G.; Whincup, P. H.; Brown, M. J.; Connell, J. M.; Dobson, R. J.; Howard, P. J.; Mein, C. A.; Onipinla, A.; Shaw-Hawkins, S.; Zhang, Y.; Davey Smith, G.; Day, I. N.; Lawlor, D. A.; Goodall, A. H.; Fowkes, F. G.; Abecasis, G. R.; Elliott, P.; Gateva, V.; Braund, P. S.; Burton, P. R.; Nelson, C. P.; Tobin, M. D.; van der Harst, P.; Glorioso, N.; Neuvrith, H.; Salvi, E.; Staessen, J. A.; Stucchi, A.; Devos, N.; Jeunemaitre, X.; Plouin, P. F.; Tichet, J.; Juhanson, P.; Org, E.; Putku, M.; Sober, S.; Veldre, G.; Viigimaa, M.; Levinsson, A.; Rosengren, A.; Thelle, D. S.; Hastie, C. E.; Hedner, T.; Lee, W. K.; Melander, O.; Wahlstrand, B.; Hardy, R.; Wong, A.; Cooper, J. A.; Palmen, J.; Chen, L.; Stewart, A. F.; Wells, G. A.; Westra, H. J.; Wolfs, M. G.; Clarke, R.; Franzosi, M. G.; Goel, A.; Hamsten, A.; Lathrop, M.; Peden, J. F.; Seedorf, U.; Watkins, H.; Ouwehand, W. H.; Sambrook, J.; Stephens, J.; Casas, J. P.; Drenos, F.; Holmes, M. V.; Kivimaki, M.; Shah, S.; Shah, T.; Talmud, P. J.; Whittaker, J.; Wallace, C.; Delles, C.; Laan, M.; Kuh, D.; Humphries, S. E.; Nyberg, F.; Cusi, D.; Roberts, R.; Newton-Cheh, C.; Franke, L.; Stanton, A. V.; Dominiczak, A. F.; Farrall, M.; Hingorani, A. D.; Samani, N. J.; Caulfield, M. J.; Munroe, P. B.

Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23443

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DC Field	Value	Language
dc.contributor.author	Johnson, T.	en
dc.contributor.author	Gaunt, T. R.	en
dc.contributor.author	Newhouse, S. J.	en
dc.contributor.author	Padmanabhan, S.	en
dc.contributor.author	Tomaszewski, M.	en
dc.contributor.author	Kumari, M.	en
dc.contributor.author	Morris, R. W.	en
dc.contributor.author	Tzoulaki, I.	en
dc.contributor.author	O'Brien, E. T.	en
dc.contributor.author	Poulter, N. R.	en
dc.contributor.author	Sever, P.	en
dc.contributor.author	Shields, D. C.	en
dc.contributor.author	Thom, S.	en
dc.contributor.author	Wannamethee, S. G.	en
dc.contributor.author	Whincup, P. H.	en
dc.contributor.author	Brown, M. J.	en
dc.contributor.author	Connell, J. M.	en
dc.contributor.author	Dobson, R. J.	en
dc.contributor.author	Howard, P. J.	en
dc.contributor.author	Mein, C. A.	en
dc.contributor.author	Onipinla, A.	en
dc.contributor.author	Shaw-Hawkins, S.	en
dc.contributor.author	Zhang, Y.	en
dc.contributor.author	Davey Smith, G.	en
dc.contributor.author	Day, I. N.	en
dc.contributor.author	Lawlor, D. A.	en
dc.contributor.author	Goodall, A. H.	en
dc.contributor.author	Fowkes, F. G.	en
dc.contributor.author	Abecasis, G. R.	en
dc.contributor.author	Elliott, P.	en
dc.contributor.author	Gateva, V.	en
dc.contributor.author	Braund, P. S.	en
dc.contributor.author	Burton, P. R.	en
dc.contributor.author	Nelson, C. P.	en
dc.contributor.author	Tobin, M. D.	en
dc.contributor.author	van der Harst, P.	en
dc.contributor.author	Glorioso, N.	en
dc.contributor.author	Neuvrith, H.	en
dc.contributor.author	Salvi, E.	en
dc.contributor.author	Staessen, J. A.	en
dc.contributor.author	Stucchi, A.	en
dc.contributor.author	Devos, N.	en
dc.contributor.author	Jeunemaitre, X.	en
dc.contributor.author	Plouin, P. F.	en
dc.contributor.author	Tichet, J.	en
dc.contributor.author	Juhanson, P.	en
dc.contributor.author	Org, E.	en
dc.contributor.author	Putku, M.	en
dc.contributor.author	Sober, S.	en
dc.contributor.author	Veldre, G.	en
dc.contributor.author	Viigimaa, M.	en
dc.contributor.author	Levinsson, A.	en
dc.contributor.author	Rosengren, A.	en
dc.contributor.author	Thelle, D. S.	en
dc.contributor.author	Hastie, C. E.	en
dc.contributor.author	Hedner, T.	en
dc.contributor.author	Lee, W. K.	en
dc.contributor.author	Melander, O.	en
dc.contributor.author	Wahlstrand, B.	en
dc.contributor.author	Hardy, R.	en
dc.contributor.author	Wong, A.	en
dc.contributor.author	Cooper, J. A.	en
dc.contributor.author	Palmen, J.	en
dc.contributor.author	Chen, L.	en
dc.contributor.author	Stewart, A. F.	en
dc.contributor.author	Wells, G. A.	en
dc.contributor.author	Westra, H. J.	en
dc.contributor.author	Wolfs, M. G.	en
dc.contributor.author	Clarke, R.	en
dc.contributor.author	Franzosi, M. G.	en
dc.contributor.author	Goel, A.	en
dc.contributor.author	Hamsten, A.	en
dc.contributor.author	Lathrop, M.	en
dc.contributor.author	Peden, J. F.	en
dc.contributor.author	Seedorf, U.	en
dc.contributor.author	Watkins, H.	en
dc.contributor.author	Ouwehand, W. H.	en
dc.contributor.author	Sambrook, J.	en
dc.contributor.author	Stephens, J.	en
dc.contributor.author	Casas, J. P.	en
dc.contributor.author	Drenos, F.	en
dc.contributor.author	Holmes, M. V.	en
dc.contributor.author	Kivimaki, M.	en
dc.contributor.author	Shah, S.	en
dc.contributor.author	Shah, T.	en
dc.contributor.author	Talmud, P. J.	en
dc.contributor.author	Whittaker, J.	en
dc.contributor.author	Wallace, C.	en
dc.contributor.author	Delles, C.	en
dc.contributor.author	Laan, M.	en
dc.contributor.author	Kuh, D.	en
dc.contributor.author	Humphries, S. E.	en
dc.contributor.author	Nyberg, F.	en
dc.contributor.author	Cusi, D.	en
dc.contributor.author	Roberts, R.	en
dc.contributor.author	Newton-Cheh, C.	en
dc.contributor.author	Franke, L.	en
dc.contributor.author	Stanton, A. V.	en
dc.contributor.author	Dominiczak, A. F.	en
dc.contributor.author	Farrall, M.	en
dc.contributor.author	Hingorani, A. D.	en
dc.contributor.author	Samani, N. J.	en
dc.contributor.author	Caulfield, M. J.	en
dc.contributor.author	Munroe, P. B.	en
dc.date.accessioned	2015-11-24T19:32:42Z	-
dc.date.available	2015-11-24T19:32:42Z	-
dc.identifier.issn	1537-6605	-
dc.identifier.uri	https://olympias.lib.uoi.gr/jspui/handle/123456789/23443	-
dc.rights	Default Licence	-
dc.subject	Adult	en
dc.subject	Aged	en
dc.subject	Blood Pressure/genetics	en
dc.subject	Case-Control Studies	en
dc.subject	Female	en
dc.subject	Gene Expression Profiling	en
dc.subject	Gene Frequency	en
dc.subject	*Genetic Loci	en
dc.subject	Genome-Wide Association Study	en
dc.subject	Haplotypes	en
dc.subject	Humans	en
dc.subject	Hypertension/*genetics	en
dc.subject	Linkage Disequilibrium	en
dc.subject	Male	en
dc.subject	Methylenetetrahydrofolate Reductase (NADPH2)/genetics	en
dc.subject	Middle Aged	en
dc.subject	*Oligonucleotide Array Sequence Analysis	en
dc.subject	Plasma Membrane Calcium-Transporting ATPases/genetics	en
dc.subject	Polymorphism, Single Nucleotide	en
dc.subject	Receptors, Atrial Natriuretic Factor/genetics	en
dc.subject	Sequence Analysis, DNA	en
dc.title	Blood pressure loci identified with a gene-centric array	en
heal.type	journalArticle	-
heal.type.en	Journal article	en
heal.type.el	Άρθρο Περιοδικού	el
heal.identifier.primary	10.1016/j.ajhg.2011.10.013	-
heal.identifier.secondary	http://www.ncbi.nlm.nih.gov/pubmed/22100073	-
heal.identifier.secondary	http://ac.els-cdn.com/S0002929711004472/1-s2.0-S0002929711004472-main.pdf?_tid=e3ca00761826390b2f6d2a2d345293e2&acdnat=1333123367_3bf77ea66b7a6581b942caa593d5e679	-
heal.language	en	-
heal.access	campus	-
heal.recordProvider	Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής	el
heal.publicationDate	2011	-
heal.abstract	Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56 x 10(-7) study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56 x 10(-7) at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies.	en
heal.journalName	Am J Hum Genet	en
heal.journalType	peer-reviewed	-
heal.fullTextAvailability	TRUE	-
Appears in Collections:	Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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