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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23392
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dc.contributor.authorvan der Merwe, D. J.en
dc.contributor.authorAndronikou, S.en
dc.contributor.authorVan Toorn, R.en
dc.contributor.authorPienaar, M.en
dc.date.accessioned2015-11-24T19:32:18Z-
dc.date.available2015-11-24T19:32:18Z-
dc.identifier.issn1433-0350-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23392-
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectBrain Ischemia/*etiology/*pathology/radiographyen
dc.subjectBrain Stem/*pathology/radiographyen
dc.subjectChild, Preschoolen
dc.subjectDiffusion Magnetic Resonance Imagingen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMovement Disorders/etiology/pathology/radiographyen
dc.subjectSensitivity and Specificityen
dc.subjectTomography, X-Ray Computeden
dc.subjectTuberculosis, Meningeal/*complications/*pathology/radiographyen
dc.titleBrainstem ischemic lesions on MRI in children with tuberculous meningitis: with diffusion weighted confirmationen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1007/s00381-009-0899-2-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19424705-
heal.identifier.secondaryhttp://www.springerlink.com/content/e033m6552w975640/fulltext.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2009-
heal.abstractINTRODUCTION: The Western Cape in South Africa has one of the highest incidences of tuberculous meningitis (TBM) in the world. Despite therapy, the outcome in children with advanced TBM remains dismal. Magnetic resonance imaging (MRI) has been shown to be superior to computed tomography (CT) in demonstrating ischemia in TBM, especially of the brainstem. The objective of this study was to characterize brainstem lesions and association with clinical findings in children with TBM by using MRI. MATERIALS AND METHODS: CT and multiplanar MRI scans were performed in 30 children with proven TBM. From this group, a subgroup with radiological ischemic changes of the brainstem were identified. Radiological findings in these patients were then correlated with severity of disease, motor deficit, and outcome after 6 months. RESULTS: Radiological brainstem abnormalities were identified in 14 out of 30 children. Thirty-eight brainstem lesions were confirmed to be ischemic. The severity of disease at presentation, degree of motor deficit, and developmental outcome after 6 months of the children with ischemic brainstem lesions was poorer compared to those children without brainstem involvement. However, both sensitivity and specificity of the MRI brainstem lesion detection for clinical outcome proved low. CONCLUSION: A significant percentage of children with TBM have ischemic brainstem lesions. These are poorly visualized on conventional CT. MRI scanning is more sensitive in detecting these lesions and localizing them. There appears to be some association between MRI-detected brainstem lesions and clinical outcome. The exact meaning of these lesions and their implication for the patient's management require further clarification.en
heal.journalNameChilds Nerv Systen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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