1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23262
Full metadata record
DC FieldValueLanguage
dc.contributor.authorEmile, J. F.en
dc.contributor.authorBoulland, M. L.en
dc.contributor.authorHaioun, C.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorPetrella, T.en
dc.contributor.authorDelfau-Larue, M. H.en
dc.contributor.authorBensussan, A.en
dc.contributor.authorFarcet, J. P.en
dc.contributor.authorGaulard, P.en
dc.date.accessioned2015-11-24T19:31:25Z-
dc.date.available2015-11-24T19:31:25Z-
dc.identifier.issn0006-4971-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23262-
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntigens, CD5/analysisen
dc.subjectAntigens, CD56/analysisen
dc.subjectClone Cellsen
dc.subjectDNA, Neoplasm/geneticsen
dc.subjectFemaleen
dc.subjectGene Rearrangement, T-Lymphocyteen
dc.subjectHumansen
dc.subjectImmunophenotypingen
dc.subjectKiller Cells, Natural/*immunologyen
dc.subjectLiver Neoplasms/pathologyen
dc.subjectLymphoma, T-Cell/*classificationen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNasopharyngeal Neoplasms/classificationen
dc.subjectReceptors, Antigen, T-Cell/analysisen
dc.subjectSplenic Neoplasms/pathologyen
dc.titleCD5-CD56+ T-cell receptor silent peripheral T-cell lymphomas are natural killer cell lymphomasen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8608237-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1996-
heal.abstractNon-Hodgkin's lymphomas are divided into B- and T-cell neoplasms. The existence and the clinical relevance of lymphomas derived from the third lymphocyte lineage, ie, natural killer (NK) cells are still controversial. NK cells are lymphocytes that mediate cytotoxicity without prior sensitization. NK cells also have phenotypic and genotypic characteristics: they express the NK-related antigen CD56, T-cell markers such as CD2 and CD7, but do not express CD5 and T-cell receptor (TCR) proteins, and their TCR locus is not rearranged. Therefore, if NK cell lymphomas exist, they should express some T-cell markers, but not alpha beta or gamma delta TCR proteins. Such lymphomas are actually called TCR silent peripheral T cell lymphomas (PTCL). To detect and characterize NK cell lymphomas, we investigated the immunophenotype and immunogenotype of 35 patients with TCR silent PTCL. The first group included 16 patients with a lymphoma of CD5-CD56+ phenotype, which is identical to normal NK cells. These patients had either a nasal/nasopharyngeal lymphoma (11 cases) or a lymphoma with predominant non-nasal/non-nodal initial involvement (five cases). Eight of the nine cases for which immunogenotypic data were available lacked clonal rearrangement of the TCR gamma genes. Thus, these tumors are likely to be NK cell lymphomas. The second group of 15 cases had a CD5+ phenotype (14 were CD56-, and 1 was CD56+) and clonal rearrangement of TCR gamma genes, indicating that they were true PTCL with unproductive TCR rearrangement. The four remaining cases were CD5- CD56- lymphomas and disclosed either a clonal (two cases) or no clonal (two cases) rearrangements of the TCR gamma genes. Altogether these findings show that CD5-CD56+ so-called "TCR silent PTCL" bear the immunophenotype and immunogenotype of normal NK cells and display peculiar clinical features distinct from true PTCL.en
heal.journalNameBlooden
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
File Description SizeFormat 
Kanavaros-1996-CD5 CD56+ T.pdf3.13 MBAdobe PDFView/Open    Request a copy
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons