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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23248
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dc.contributor.authorPeschos, D.en
dc.contributor.authorStefanou, D.en
dc.contributor.authorVougiouklakis, T.en
dc.contributor.authorAssimakopoulos, D. A.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:31:20Z-
dc.date.available2015-11-24T19:31:20Z-
dc.identifier.issn0392-9078-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23248-
dc.rightsDefault Licence-
dc.subjectCarcinoma, Squamous Cell/immunology/*metabolism/pathology/therapyen
dc.subjectCell Cycle Proteins/*metabolismen
dc.subject*Cell Proliferationen
dc.subjectCohort Studiesen
dc.subjectCyclin-Dependent Kinases/antagonists & inhibitorsen
dc.subjectCyclins/metabolismen
dc.subjectEnzyme Inhibitors/metabolismen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectImmunophenotypingen
dc.subjectKi-67 Antigen/metabolismen
dc.subjectLaryngeal Neoplasms/immunology/*metabolism/pathology/therapyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrognosisen
dc.subjectProliferating Cell Nuclear Antigen/metabolismen
dc.subjectRetrospective Studiesen
dc.subjectSurvival Rateen
dc.subjectTreatment Outcomeen
dc.subjectTumor Suppressor Protein p53/metabolismen
dc.titleCell cycle proteins in laryngeal cancer: role in proliferation and prognosisen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16270530-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2005-
heal.abstractA study of laryngeal carcinomas was performed in order to analyze (a) the expression of p53/p21, cyclin D1/cyclin E, p21/p27 (b) the relation of normal and abnormal protein expression, with the proliferation status, as determined by the expression of Ki67 and PCNA and (c) the correlation of our findings with prognosis. We performed a retrospective analysis of 57 cases of squamous cell carcinomas of the larynx. We applied monoclonal antibodies against p53, p21, p27, cyclin D1, cyclin E, Ki67 and PCNA, using streptavidin-biotin method. Analysis of the p53/p21 proteins, revealed abnormalities in 25/37 cases (67.57%), while 12/37 (32.43%) cases displayed normal phenotype (p53-/p21-). Analysis of cyclins revealed overexpression in 17/48 cases (35.42), while the majority 31/48(64.58%) displayed normal phenotype (cyclin D1-/cyclin E-). Concerning CDKIs expression, the majority 30/50(60%) presented high levels of both inhibitors (p21+/p27+). Cases with simultaneous overexpression of CDKIs demonstrated significantly higher levels of Ki67 protein (p = 0.05). Analysis of p53/p21, cyclin D/cyclin E, p21/p27 patterns showed no association between the presence of one or two alterations and prognosis. In conclusion, we demonstrated that p53 tumor suppressor pathway is frequently disrupted in laryngeal cancer. Furthermore, levels of CDKIs, although they act as cell cycle activity blockers, are not reliable markers for the estimation of laryngeal neoplastic cells growth fraction.en
heal.journalNameJ Exp Clin Cancer Resen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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