Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23209
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dc.contributor.authorMakis, A. C.en
dc.contributor.authorHatzimichael, E. C.en
dc.contributor.authorBourantas, K. L.en
dc.date.accessioned2015-11-24T19:31:07Z-
dc.date.available2015-11-24T19:31:07Z-
dc.identifier.issn0939-5555-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23209-
dc.rightsDefault Licence-
dc.subjectCytokines/*physiologyen
dc.subjectHumansen
dc.subjectSickle Cell Trait/etiology/*physiopathologyen
dc.titleThe role of cytokines in sickle cell diseaseen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10985359-
heal.identifier.secondaryhttp://www.springerlink.com/content/qdbrjpk75l31n79g/fulltext.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2000-
heal.abstractSickle cell disease (SCD) is characterized by chronic hemolysis, frequent infections, and recurrent occlusions of microcirculation, which cause painful crises and result in chronic organ damage and failure. Occlusions of the microcirculation and infections are important factors that stimulate the production of cytokines and acute-phase proteins. Cytokines seem to be involved with several possible mechanisms in the pathogenesis of vasoocclusive phenomena in SCD: vascular endothelial activation, induction of red-cell adhesiveness to vascular endothelium, induction of neutrophil adhesiveness to endothelium, development of vascular intimal hyperplasia, platelet activation, endothelin-1 production, and dysregulation of endothelial apoptosis. Cytokines are also thought to be involved in the regulation of hemopoiesis, the inhibition of immune functions, and the development of growth deficits. Investigation of cytokines in SCD patients will elucidate the pathogenesis of the disease and its complications and may help in assessing disease severity and prognosis.en
heal.journalNameAnn Hematolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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