Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23180
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dc.contributor.authorKolettis, T.en
dc.contributor.authorVlahos, A. P.en
dc.contributor.authorLouka, M.en
dc.contributor.authorHatzistergos, K. E.en
dc.contributor.authorBaltogiannis, G. G.en
dc.contributor.authorAgelaki, M. M.en
dc.contributor.authorMitsi, A.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.date.accessioned2015-11-24T19:30:52Z-
dc.date.available2015-11-24T19:30:52Z-
dc.identifier.issn1109-9666-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23180-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBlood Pressure Determination/*methodsen
dc.subject*Disease Models, Animalen
dc.subjectEndothelin-2/deficiencyen
dc.subjectFeasibility Studiesen
dc.subjectFemaleen
dc.subjectHypertension, Pulmonary/chemically induced/*physiopathologyen
dc.subjectMaleen
dc.subjectMonocrotalineen
dc.subjectRatsen
dc.subjectThoracotomyen
dc.titleCharacterisation of a rat model of pulmonary arterial hypertensionen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17715611-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2007-
heal.abstractINTRODUCTION: Pulmonary hypertension portends an adverse outcome. Animal models have improved current understanding of the complex pathophysiology of the disease, but may be technically demanding. Moreover, plexiform vascular lesions are rarely observed, limiting the extrapolation to human pathophysiology. The aim of the present study was first, to assess the feasibility of closed-chest pressure recordings, and mainly, to further characterise a new model of endothelin receptor-B deficient rats. METHODS: Jugular venous catheterisation was assessed in 15 Wistar rats. Pressure recordings via a left lateral thoracotomy and histological findings were compared in three rat groups (age 20 +/- 1 weeks, weight 200-250 g): (a) wild type (n = 10, group A); (b) wild type after monocrotaline injection (n=10, group B); and (c) endothelin receptor-B deficient rats (n = 10, group C) after monocrotaline injection. RESULTS: Pressure recordings via the jugular approach were feasible in only 3 (20%) rats. Compared to group A, there was a trend (H = 4.6, p = 0.0962) towards increased mortality in groups B and C, due to respiratory arrest during intubation attempts. Pulmonary artery systolic pressure in group C was 24.7 +/- 1.3 mmHg, higher than in group B (21.5 +/- 1.2, p = 0.036) or group A (11.8 +/- 0.5, p < 0.0001). Adverse pulmonary vascular remodelling was more prominent in group C than in group B. CONCLUSIONS: Endothelin receptor-B deficient rats constitute a useful model of pulmonary artery hypertension after monocrotaline injection. The ease of pressure recordings via a left lateral thoracotomy may aid in the more widespread use of this model.en
heal.journalNameHellenic J Cardiolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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