1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23154
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBriasoulis, E.en
dc.contributor.authorFroudarakis, M.en
dc.contributor.authorMilionis, H. J.en
dc.contributor.authorPeponis, I.en
dc.contributor.authorConstantopoulos, S.en
dc.contributor.authorPavlidis, N.en
dc.date.accessioned2015-11-24T19:30:42Z-
dc.date.available2015-11-24T19:30:42Z-
dc.identifier.issn0025-7931-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23154-
dc.rightsDefault Licence-
dc.subjectAdrenal Cortex Hormones/therapeutic useen
dc.subjectAgeden
dc.subjectAntimetabolites, Antineoplastic/*adverse effectsen
dc.subjectAntineoplastic Agents, Phytogenic/*adverse effectsen
dc.subjectBreast Neoplasms/pathologyen
dc.subjectDeoxycytidine/*adverse effects/analogs & derivativesen
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectGranulocyte Colony-Stimulating Factor/*adverse effectsen
dc.subjectHumansen
dc.subjectLiver Neoplasms/drug therapy/secondaryen
dc.subjectLymphatic Metastasisen
dc.subjectPaclitaxel/*adverse effects/*analogs & derivativesen
dc.subjectPulmonary Edema/*chemically induced/drug therapy/radiographyen
dc.subject*Taxoidsen
dc.titleChemotherapy-induced noncardiogenic pulmonary edema related to gemcitabine plus docetaxel combination with granulocyte colony-stimulating factor supporten
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11124653-
heal.identifier.secondaryhttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000056300&Ausgabe=228220&ProduktNr=224278&filename=000056300.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2000-
heal.abstractSeveral cancer therapeutic agents have been associated with pulmonary toxicity. Herein, we describe the case of a 73-year-old woman with breast cancer metastatic to the liver, who developed noncardiogenic pulmonary edema (NPE) while on treatment with gemcitabine plus docetaxel combination with granulocyte colony-stimulating factor (G-CSF) support. Gemcitabine, a deoxycytidine analogue, is reported to produce mild self-limiting and only occasionally severe pulmonary toxicity. The microtubule stabilizer docetaxel has been associated with water retention complications. The combination of these two agents has shown promising activity in several solid tumors and is in a phase of clinical development with prophylactic G-CSF in most of the trials due to the high rate of dose-limiting neutropenia observed with this combination. In our case pulmonary toxicity resolved rapidly following the administration of corticosteroids. A possible deleterious synergy of the compounds involved in this case is discussed and the medical literature on NPE related to cancer therapy is shortly reviewed. We conclude that NPE should always be considered in patients with respiratory function deterioration while on therapy with the gemcitabine-docetaxel combination and G-CSF. Corticosteroids can provide maximum benefit if started early upon diagnosis coupled with withdrawal of the causative drugs.en
heal.journalNameRespirationen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
File Description SizeFormat 
Briasoulis-2000-Chemotherapy-induced.pdf187.97 kBAdobe PDFView/Open    Request a copy
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons