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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23140
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dc.contributor.authorKoufaki, M.en
dc.contributor.authorTheodorou, E.en
dc.contributor.authorGalaris, D.en
dc.contributor.authorNousis, L.en
dc.contributor.authorKatsanou, E. S.en
dc.contributor.authorAlexis, M. N.en
dc.date.accessioned2015-11-24T19:30:39Z-
dc.date.available2015-11-24T19:30:39Z-
dc.identifier.issn0022-2623-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23140-
dc.rightsDefault Licence-
dc.subjectAntioxidants/*chemical synthesis/chemistry/*pharmacologyen
dc.subjectCatechols/*chemistryen
dc.subjectCell Death/drug effectsen
dc.subjectCell Lineen
dc.subjectChromans/*chemical synthesis/chemistry/*pharmacologyen
dc.subjectDNA Damageen
dc.subjectDrug Evaluation, Preclinicalen
dc.subjectHumansen
dc.subjectHydrogen Peroxide/pharmacologyen
dc.subjectMolecular Structureen
dc.subjectOxidative Stress/*drug effects/physiologyen
dc.subjectStereoisomerismen
dc.titleChroman/catechol hybrids: synthesis and evaluation of their activity against oxidative stress induced cellular damageen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1021/jm0506120-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16392814-
heal.identifier.secondaryhttp://pubs.acs.org/doi/pdfplus/10.1021/jm0506120-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2006-
heal.abstractThree series of chromans substituted at positions 2 or 5 by catechol derivatives were synthesized, and their activity against oxidative stress induced cellular damage was studied. Specifically, the ability of the new molecules to protect cultured cells from H(2)O(2)-induced DNA damage was evaluated using single cell gel electrophoresis (comet assay), while the neuroprotective activity of the new compounds against oxidative stress induced programmed cell death was studied using glutamate-challanged hippocampal HT22 cells. The majority of the new compounds are stronger neuroprotectants than quercetin. 5-Substituted chroman analogues such as the caffeic acid amides 12 and 16 and the dihydrostilbene analogue 24 were the most potent against both H(2)O(2)- and glutamate-induced damage in Jurkat T cells and HT22 cells, respectively.en
heal.journalNameJ Med Chemen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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