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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Siminelakis, S. | en |
| dc.contributor.author | Kotsanti, A. | en |
| dc.contributor.author | Kolaitis, N. | en |
| dc.contributor.author | Niokou, D. | en |
| dc.contributor.author | Vlachou, I. | en |
| dc.contributor.author | Dimakopoulos, G. | en |
| dc.contributor.author | Papadopoulou, C. | en |
| dc.date.accessioned | 2015-11-24T19:30:30Z | - |
| dc.date.available | 2015-11-24T19:30:30Z | - |
| dc.identifier.issn | 1522-6662 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23110 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Biological Markers/blood | en |
| dc.subject | Matrix Metalloproteinase 3/*blood | en |
| dc.subject | Myocardial Ischemia/*blood/*enzymology | en |
| dc.subject | Rabbits | en |
| dc.title | Circulating matrix metalloproteinase 3 due to myocardial ischemia | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1532/HSF98.20081152 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19683995 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2009 | - |
| heal.abstract | BACKGROUND: Experimental data suggest that matrix metalloproteinases (MMPs) such as MMP-3 have a central role in the remodeling period after a myocardial infarction (MI). The aim of this study was to use an experimental small-animal model to investigate the fluctuation in MMP-3 levels occurring in vivo after an acute MI. METHODS: We studied 13 New Zealand white rabbits weighing between 3 and 4 kg. After anesthetizing the animals, we performed a tracheotomy and induced an acute MI in 10 of the animals by occluding the left anterior descending coronary artery for 45 minutes. The remaining 3 rabbits constituted the control group. Three hours after reperfusion, blood samples were taken for biomedical analyses. RESULTS: Three hours after the artificially induced acute MI, serum MMP-3 levels were decreased by almost 50%. Cardiac troponin I (cTnI) concentrations were increased greatly (90-fold) after MI, further validating the efficiency of our experimental in vivo model of acute MI. CONCLUSION: Combining the data, we demonstrated that acute MI caused an early reduction in MMP-3 levels. The range of MMP-3 reduction is limited compared with other factors predicting MI, such as cTnI, which increases its usefulness. We demonstrated, however, that plasma fluctuation in MMP-3 levels could be used as a supplementary independent predictor of cardiovascular events in patients with stable coronary artery disease. This acute MI model used in our controlled setting proved to be a reliable and safe method for conducting in vivo studies. | en |
| heal.journalName | Heart Surg Forum | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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