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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/23043
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dc.contributor.authorIoachim, E.en
dc.contributor.authorTsanou, E.en
dc.contributor.authorBriasoulis, E.en
dc.contributor.authorBatsis, C.en
dc.contributor.authorKaravasilis, V.en
dc.contributor.authorCharchanti, A.en
dc.contributor.authorPavlidis, N.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:30:12Z-
dc.date.available2015-11-24T19:30:12Z-
dc.identifier.issn0960-9776-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23043-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAnalysis of Varianceen
dc.subjectBiopsy, Needleen
dc.subjectBreast Neoplasms/metabolism/*pathologyen
dc.subjectCarcinoma, Ductal, Breast/metabolism/mortality/pathologyen
dc.subjectCathepsin D/analysis/*metabolismen
dc.subjectChi-Square Distributionen
dc.subjectCohort Studiesen
dc.subjectFemaleen
dc.subjectHeat-Shock Proteins/analysis/*metabolismen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectMetallothionein/analysis/*metabolismen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Invasiveness/pathologyen
dc.subjectNeoplasm Proteins/analysis/metabolismen
dc.subjectProbabilityen
dc.subjectPrognosisen
dc.subjectProteins/analysis/*metabolismen
dc.subjectSensitivity and Specificityen
dc.subjectSurvival Analysisen
dc.subjectTumor Markers, Biological/*analysisen
dc.subjectTumor Suppressor Protein p53/analysisen
dc.subjectTumor Suppressor Proteinsen
dc.titleClinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast canceren
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/14659340-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0960977602002904/1-s2.0-S0960977602002904-main.pdf?_tid=bed18a7190bd1a41ebe58f8302393532&acdnat=1333703235_ce4b2c2a29dad68d4533fe6eb5c291b5-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2003-
heal.abstractExpression of the hormone-related proteins hsp27, pS2, and also of cathepsin D (CD) and metallothionein (MT) was studied by immunohistochemistry and analyzed against clinical data in breast cancer. Archived material of paraffin-embedded breast carcinoma tissues from a cohort of 134 patients with primary invasive breast cancer was used. Hsp27 and pS2 (>10% of tumor cells stained) were found to be expressed in 63.6% and 37.6% of cases, respectively, and were correlated negatively with grading (P=0.006 and 0.01) and positively with estrogen receptors (ER) (P=0.04 and 0.04). pS2 expression was correlated with lymph node status (P=0.02), tumor size (P=0.01), progesterone receptor (PR) content (P=0.02), hsp27 (P=0.015) and bcl-2 protein (P=0.001). An inverse relationship between pS2 expression and the expression of p53 protein (P=0.005) and proliferation-associated index MIB1 (P<0.0001) was noted. Stromal cathepsin D was positively correlated with tumor grade (P=0.01), PCNA (P=0.007), MIB1 (P=0.001) and p53 (P=0.01), and negatively with ER (P=0.04) and bcl-2 (P<0.0001). MT was correlated positively with stromal CD (P=0.007) and inversely with PgR (P=0.04). Univariate analysis showed CD expression to be a positive prognostic factor for survival (P=0.035), with borderline significance, while MT was more strongly positive (P=0.01). However, none of the proteins studied was found to be related to disease outcome in univariate analysis. Our data show that hsp27, pS2 and stromal CD expression may reflect tumor differentiation and the functional status of ER in breast cancer, but stromal CD and tumor MT expression were the only factors found that may be of limited prognostic value.en
heal.journalNameBreasten
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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