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https://olympias.lib.uoi.gr/jspui/handle/123456789/22939Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Agelaki, M. G. | en |
| dc.contributor.author | Pantos, C. | en |
| dc.contributor.author | Korantzopoulos, P. | en |
| dc.contributor.author | Tsalikakis, D. G. | en |
| dc.contributor.author | Baltogiannis, G. G. | en |
| dc.contributor.author | Fotopoulos, A. | en |
| dc.contributor.author | Kolettis, T. M. | en |
| dc.date.accessioned | 2015-11-24T19:28:59Z | - |
| dc.date.available | 2015-11-24T19:28:59Z | - |
| dc.identifier.issn | 0014-2999 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22939 | - |
| dc.rights | Default Licence | - |
| dc.subject | Action Potentials/drug effects | en |
| dc.subject | Amiodarone/*analogs & derivatives/pharmacology/*therapeutic use | en |
| dc.subject | Animals | en |
| dc.subject | Anti-Arrhythmia Agents/pharmacology/*therapeutic use | en |
| dc.subject | Disease Models, Animal | en |
| dc.subject | Electrocardiography, Ambulatory | en |
| dc.subject | Epinephrine/metabolism | en |
| dc.subject | Female | en |
| dc.subject | Myocardial Infarction/complications/*drug therapy/mortality | en |
| dc.subject | Norepinephrine/metabolism | en |
| dc.subject | Radioimmunoassay | en |
| dc.subject | Random Allocation | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Tachycardia, Ventricular/drug therapy | en |
| dc.subject | Telemetry | en |
| dc.subject | Thyroid Hormones/metabolism | en |
| dc.subject | Ventricular Fibrillation/drug therapy | en |
| dc.title | Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.ejphar.2007.02.052 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17391666 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0014299907003032/1-s2.0-S0014299907003032-main.pdf?_tid=784d7682229f692a559052cc0f1f8617&acdnat=1333962969_11fe7963b3289e06ff27eb40b417dd60 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2007 | - |
| heal.abstract | The effects of dronedarone, a non-iodinated derivative of amiodarone, on ventricular tachycardia and ventricular fibrillation post-myocardial infarction are not well established. Fifty-five Wistar rats were randomly allocated to a 2-week oral treatment with either vehicle (n=18), amiodarone (30 mg/kg, n=20), or dronedarone (30 mg/kg, n=17). After acute coronary artery ligation, a single-lead electrocardiogram was continuously recorded for 24 h and episodes of ventricular tachycardia/fibrillation as well as mortality rates were analysed. Monophasic action potential recordings were obtained from the left ventricular epicardium at baseline and 24 h post-myocardial infarction. Thyroid hormones and catecholamines were measured using radioimmunoassay. Thyroid function was similar in the 3 groups. Compared to controls, amiodarone and dronedarone equally decreased the number of ventricular tachycardia/fibrillation episodes by approximately 75%. Both agents prevented the increase in monophasic action potential duration and in beat-to-beat variation. Norepinephrine levels were lower only after amiodarone treatment. Despite the observed antiarrhythmic effect, total mortality did not differ between groups (38.8% in controls, 30.0% in the amiodarone group and 58.8% in the dronedarone group), because of excess bradyarrhythmic mortality in both drug groups that reached significance in the dronedarone group. Dronedarone and amiodarone display similar antiarrhythmic efficacy post-myocardial infarction, partly by preventing repolarization inhomogeneity. However, dronedarone increases bradyarrhythmic mortality possibly secondary to its negative inotropic effects. | en |
| heal.journalName | European Journal of Pharmacology | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Agelaki-2007-Comparative antiarrh.pdf | 373.67 kB | Adobe PDF | View/Open Request a copy |
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