Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22895
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dc.contributor.authorKontostolis, E.en
dc.contributor.authorStefanidis, K.en
dc.contributor.authorNavrozoglou, I.en
dc.contributor.authorLolis, D.en
dc.date.accessioned2015-11-24T19:28:25Z-
dc.date.available2015-11-24T19:28:25Z-
dc.identifier.issn0951-3590-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22895-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectCohort Studiesen
dc.subjectDanazol/adverse effects/*therapeutic useen
dc.subjectEstrogen Antagonists/adverse effects/*therapeutic useen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectPain/drug therapy/etiologyen
dc.subjectPremenstrual Syndrome/*drug therapyen
dc.subjectProspective Studiesen
dc.subjectReference Valuesen
dc.subjectTamoxifen/adverse effects/*therapeutic useen
dc.titleComparison of tamoxifen with danazol for treatment of cyclical mastalgiaen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9476088-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1997-
heal.abstractThis study evaluates the benefits and side-effects of two drugs (tamoxifen or danazol) used randomly in women with severe cyclical mastalgia. Ninety-three patients with severe cyclical mastalgia of more than 6 months duration were randomly selected for treatment with tamoxifen (32 women), danazol (32 women) or placebo (29 women) for six consecutive cycles. A standard protocol was used, which included pain relief as measured by linear analog, side-effects and cost. Statistical analysis was performed using the non-parametric Mann-Whitney U or Kruskall-Wallis tests and Student's t-test. As measured by linear analog scoring, pain relief was achieved in 23/32 (72%) of those receiving tamoxifen, 21/32 (65%) of those taking danazol (p < or = 0.001) and 11/29 (38%) of those taking placebo. Twelve months after the end of treatment, 17 (53%) women who received tamoxifen were still free of symptoms, as compared with 12 (37%) of the danazol-treated patients (p < 0.001) and none of the placebo-treated patients. These results suggest that tamoxifen is highly efficaceous and cost effective for the management of severe cyclical mastalgia.en
heal.journalNameGynecol Endocrinolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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