Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22893
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dc.contributor.authorMitselou, A.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorNakanishi, Y.en
dc.contributor.authorHirohashi, S.en
dc.contributor.authorVougiouklakis, T.en
dc.contributor.authorCharalabopoulos, K.en
dc.date.accessioned2015-11-24T19:28:24Z-
dc.date.available2015-11-24T19:28:24Z-
dc.identifier.issn1699-5848-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22893-
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/*chemistry/secondaryen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCadherins/*analysisen
dc.subjectCarcinoma, Large Cell/*chemistry/secondaryen
dc.subjectCarcinoma, Non-Small-Cell Lung/*chemistry/secondaryen
dc.subjectCarcinoma, Small Cell/*chemistry/secondaryen
dc.subjectCarcinoma, Squamous Cell/*chemistry/secondaryen
dc.subjectChi-Square Distributionen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLung Neoplasms/*chemistry/pathologyen
dc.subjectMaleen
dc.subjectMembrane Glycoproteins/*analysisen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Invasivenessen
dc.subjectNeoplasm Proteins/*analysisen
dc.subjectNeoplasm Stagingen
dc.subjectPrognosisen
dc.subjectTumor Markers, Biological/*analysisen
dc.titleComparison of the dysadherin and E-cadherin expression in primary lung cancer and metastatic sitesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20712010-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractDysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell lung carcinoma, little is known about its expression at the distant metastases sites. We investigate by immunohistochemistry the relationship between E-cadherin and dysadherin in 111 cases of primary lung carcinomas (53 squamous cell carcinomas, 21 adenocarcinomas, 13 large cell carcinomas, and 24 small cell carcinomas), and their distant metastases. The intensity, the expression pattern and the percentage of neoplastic cell staining were recorded and the results were correlated with clinicopathological findings of the subjects. Dysadherin immunostain was expressed in 61 (54.95%) of the cases, and increased dysadherin expression was significantly correlated with tumour size (p=0.003), distant metastases (p=0.0034), and metastasis size (p=0.0008). Reduced E-cadherin expression was noted in 46 (41.45%) of the cases, and was correlated with high-grade tumour (p=0.02), infiltrative growth pattern (p=0.042), and advanced stage (p=0.032). Although the correlation between the expression of dysadherin and E-cadherin was not significant, a group of patients showed reduced E-cadherin expression with dysadherin overexpression. In lung carcinomas dysadherin expression seems to reflect tumour aggressiveness and may be considered a positive marker of poor prognosis when considered alone or/and in combination with down-regulation of E-cadherin.en
heal.journalNameHistol Histopatholen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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