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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Evangelou, A. | en |
| dc.contributor.author | Karkabounas, S. | en |
| dc.contributor.author | Kalpouzos, G. | en |
| dc.contributor.author | Malamas, M. | en |
| dc.contributor.author | Liasko, R. | en |
| dc.contributor.author | Stefanou, D. | en |
| dc.contributor.author | Vlahos, A. T. | en |
| dc.contributor.author | Kabanos, T. A. | en |
| dc.date.accessioned | 2015-11-24T19:28:17Z | - |
| dc.date.available | 2015-11-24T19:28:17Z | - |
| dc.identifier.issn | 0304-3835 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22886 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Antineoplastic Agents/*therapeutic use | en |
| dc.subject | Benzo(a)pyrene | en |
| dc.subject | Carcinogens | en |
| dc.subject | Drug Screening Assays, Antitumor | en |
| dc.subject | Leiomyosarcoma/chemically induced/*drug therapy | en |
| dc.subject | Male | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Sarcoma, Experimental/chemically induced/*drug therapy | en |
| dc.subject | Survival Analysis | en |
| dc.subject | Vanadium Compounds/*therapeutic use | en |
| dc.title | Comparison of the therapeutic effects of two vanadium complexes administered at low dose on benzo[a]pyrene-induced malignant tumors in rats | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9570375 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0304383597002784/1-s2.0-S0304383597002784-main.pdf?_tid=102eef0df57a95761e38532fce1a5b65&acdnat=1332928200_b31c17c6fb753caced31b6bc9ec0efb2 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1997 | - |
| heal.abstract | The antitumor effects of low dose administration of the vanadium(III) complexes with L-cysteine (complex 1) and N-(2-mercaptopropionyl)-glycine (complex 2) were compared on benzo[a]pyrene (BaP)-induced tumors in Wistar rats. Male Wistar rats, injected with 10.0 mg of BaP, were divided into one control (C-G) and two treatment (TR-G) groups of 17 animals each. Animals of the first treatment group were administered complex 2 (TR-2 group) and those of the second group were administered complex 1 (TR-1 group) at doses of 100 microg of vanadium per os daily, starting from the day a palpable tumor was developed till their death. BaP injection induced a 100% tumor (leiomyosarcomas) development in the animals of all groups. Administration of complex 1 to the animals resulted in a significant prolongation of the mean survival time, a complete remission of 17.6% of the tumors developed, a significant reduction of the carcinogenic potency (CP) of BaP and of the tumor growth rate (TGR) in TR-1 group animals, compared to the control and the TR-2 group. In marked contrast, complex 2 failed at the doses administered to exert any significant modulation of the above mentioned parameters. Results indicate that at low (100 micro/day) concentrations of vanadium, complex 1 exerts a significant anticarcinogenic effect on experimentally-induced leiomyosarcomas in rats, whereas complex 2 has no effect when administered at the same low concentrations of vanadium. | en |
| heal.journalName | Cancer Lett | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Evangelou-1997-Comparison of the th.pdf | 477.12 kB | Adobe PDF | View/Open Request a copy |
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