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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22867
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dc.contributor.authorChatzinasiou, F.en
dc.contributor.authorLill, C. M.en
dc.contributor.authorKypreou, K.en
dc.contributor.authorStefanaki, I.en
dc.contributor.authorNicolaou, V.en
dc.contributor.authorSpyrou, G.en
dc.contributor.authorEvangelou, E.en
dc.contributor.authorRoehr, J. T.en
dc.contributor.authorKodela, E.en
dc.contributor.authorKatsambas, A.en
dc.contributor.authorTsao, H.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorBertram, L.en
dc.contributor.authorStratigos, A. J.en
dc.date.accessioned2015-11-24T19:28:04Z-
dc.date.available2015-11-24T19:28:04Z-
dc.identifier.issn1460-2105-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22867-
dc.rightsDefault Licence-
dc.subjectAgouti Signaling Protein/geneticsen
dc.subjectAntigens, Neoplasm/geneticsen
dc.subjectCardiac Myosins/geneticsen
dc.subjectConfounding Factors (Epidemiology)en
dc.subjectCyclin-Dependent Kinase Inhibitor p16/geneticsen
dc.subjectDatabases, Geneticen
dc.subjectGene Frequencyen
dc.subjectGenome-Wide Association Studyen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectMelanoma/*epidemiology/*geneticsen
dc.subjectMembrane Glycoproteins/geneticsen
dc.subjectMembrane Proteins/geneticsen
dc.subjectMembrane Transport Proteins/geneticsen
dc.subjectMeta-Analysis as Topicen
dc.subjectMolecular Epidemiologyen
dc.subjectMyosin Heavy Chains/geneticsen
dc.subjectNeoplasm Proteins/geneticsen
dc.subjectOxidoreductases/geneticsen
dc.subject*Polymorphism, Single Nucleotideen
dc.subjectReceptor, Melanocortin, Type 1/geneticsen
dc.subjectReceptors, Calcitriol/geneticsen
dc.subjectReproducibility of Resultsen
dc.subjectResearch Designen
dc.subjectSkin Neoplasms/*epidemiology/*geneticsen
dc.titleComprehensive field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanomaen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1093/jnci/djr219-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21693730-
heal.identifier.secondaryhttp://jnci.oxfordjournals.org/content/103/16/1227.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2011-
heal.abstractBACKGROUND: Although genetic studies have reported a number of loci associated with cutaneous melanoma (CM) risk, a comprehensive synopsis of genetic association studies published in the field and systematic meta-analysis for all eligible polymorphisms have not been reported. METHODS: We systematically annotated data from all genetic association studies published in the CM field (n = 145), including data from genome-wide association studies (GWAS), and performed random-effects meta-analyses across all eligible polymorphisms on the basis of four or more independent case-control datasets in the main analyses. Supplementary analyses of three available datasets derived from GWAS and GWAS-replication studies were also done. Nominally statistically significant associations between polymorphisms and CM were graded for the strength of epidemiological evidence on the basis of the Human Genome Epidemiology Network Venice criteria. All statistical tests were two-sided. RESULTS: Forty-two polymorphisms across 18 independent loci evaluated in four or more datasets including candidate gene studies and available GWAS data were subjected to meta-analysis. Eight loci were identified in the main meta-analyses as being associated with a risk of CM (P < .05) of which four loci showed a genome-wide statistically significant association (P < 1 x 10(-7)), including 16q24.3 (MC1R), 20q11.22 (MYH7B/PIGU/ASIP), 11q14.3 (TYR), and 5p13.2 (SLC45A2). Grading of the cumulative evidence by the Venice criteria suggested strong epidemiological credibility for all four loci with genome-wide statistical significance and one additional gene at 9p23 (TYRP1). In the supplementary meta-analyses, a locus at 9p21.3 (CDKN2A/MTAP) reached genome-wide statistical significance with CM and had strong epidemiological credibility. CONCLUSIONS: To the best of our knowledge, this is the first comprehensive field synopsis and systematic meta-analysis to identify genes associated with an increased susceptibility to CM.en
heal.journalNameJ Natl Cancer Insten
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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