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dc.contributor.authorLill, C. M.en
dc.contributor.authorRoehr, J. T.en
dc.contributor.authorMcQueen, M. B.en
dc.contributor.authorKavvoura, F. K.en
dc.contributor.authorBagade, S.en
dc.contributor.authorSchjeide, B. M.en
dc.contributor.authorSchjeide, L. M.en
dc.contributor.authorMeissner, E.en
dc.contributor.authorZauft, U.en
dc.contributor.authorAllen, N. C.en
dc.contributor.authorLiu, T.en
dc.contributor.authorSchilling, M.en
dc.contributor.authorAnderson, K. J.en
dc.contributor.authorBeecham, G.en
dc.contributor.authorBerg, D.en
dc.contributor.authorBiernacka, J. M.en
dc.contributor.authorBrice, A.en
dc.contributor.authorDestefano, A. L.en
dc.contributor.authorDo, C. B.en
dc.contributor.authorEriksson, N.en
dc.contributor.authorFactor, S. A.en
dc.contributor.authorFarrer, M. J.en
dc.contributor.authorForoud, T.en
dc.contributor.authorGasser, T.en
dc.contributor.authorHamza, T.en
dc.contributor.authorHardy, J. A.en
dc.contributor.authorHeutink, P.en
dc.contributor.authorHill-Burns, E. M.en
dc.contributor.authorKlein, C.en
dc.contributor.authorLatourelle, J. C.en
dc.contributor.authorMaraganore, D. M.en
dc.contributor.authorMartin, E. R.en
dc.contributor.authorMartinez, M.en
dc.contributor.authorMyers, R. H.en
dc.contributor.authorNalls, M. A.en
dc.contributor.authorPankratz, N.en
dc.contributor.authorPayami, H.en
dc.contributor.authorSatake, W.en
dc.contributor.authorScott, W. K.en
dc.contributor.authorSharma, M.en
dc.contributor.authorSingleton, A. B.en
dc.contributor.authorStefansson, K.en
dc.contributor.authorToda, T.en
dc.contributor.authorTung, J. Y.en
dc.contributor.authorVance, J.en
dc.contributor.authorWood, N. W.en
dc.contributor.authorZabetian, C. P.en
dc.contributor.authorYoung, P.en
dc.contributor.authorTanzi, R. E.en
dc.contributor.authorKhoury, M. J.en
dc.contributor.authorZipp, F.en
dc.contributor.authorLehrach, H.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorBertram, L.en
dc.date.accessioned2015-11-24T19:28:03Z-
dc.date.available2015-11-24T19:28:03Z-
dc.identifier.issn1553-7404-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22866-
dc.rightsDefault Licence-
dc.titleComprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Databaseen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1371/journal.pgen.1002548-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/22438815-
heal.identifier.secondaryhttp://www.plosgenetics.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pgen.1002548&representation=PDF-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2012-
heal.abstractMore than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively collects and meta-analyzes all published studies in the field. A systematic literature screen of approximately 27,000 articles yielded 828 eligible articles from which relevant data were extracted. In addition, individual-level data from three publicly available genome-wide association studies (GWAS) were obtained and subjected to genotype imputation and analysis. Overall, we performed meta-analyses on more than seven million polymorphisms originating either from GWAS datasets and/or from smaller scale PD association studies. Meta-analyses on 147 SNPs were supplemented by unpublished GWAS data from up to 16,452 PD cases and 48,810 controls. Eleven loci showed genome-wide significant (P<5x10(-8)) association with disease risk: BST1, CCDC62/HIP1R, DGKQ/GAK, GBA, LRRK2, MAPT, MCCC1/LAMP3, PARK16, SNCA, STK39, and SYT11/RAB25. In addition, we identified novel evidence for genome-wide significant association with a polymorphism in ITGA8 (rs7077361, OR 0.88, P = 1.3x10(-8)). All meta-analysis results are freely available on a dedicated online database (www.pdgene.org), which is cross-linked with a customized track on the UCSC Genome Browser. Our study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies.en
heal.journalNamePLoS Geneten
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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