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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22828
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dc.contributor.authorMintzopoulos, D.en
dc.contributor.authorAstrakas, L. G.en
dc.contributor.authorKhanicheh, A.en
dc.contributor.authorKonstas, A. A.en
dc.contributor.authorSinghal, A.en
dc.contributor.authorMoskowitz, M. A.en
dc.contributor.authorRosen, B. R.en
dc.contributor.authorTzika, A. A.en
dc.date.accessioned2015-11-24T19:27:36Z-
dc.date.available2015-11-24T19:27:36Z-
dc.identifier.issn1095-9572-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22828-
dc.rightsDefault Licence-
dc.subjectAlgorithmsen
dc.subjectAnalysis of Varianceen
dc.subjectBrain/*physiopathologyen
dc.subjectCerebellum/physiopathologyen
dc.subjectFrontal Lobe/physiopathologyen
dc.subjectHanden
dc.subjectHumansen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectModels, Neurologicalen
dc.subjectMotor Activity/*physiologyen
dc.subjectMotor Cortex/physiopathologyen
dc.subjectNeural Pathways/physiopathologyen
dc.subject*Neuronal Plasticityen
dc.subjectRoboticsen
dc.subjectStroke/*physiopathologyen
dc.titleConnectivity alterations assessed by combining fMRI and MR-compatible hand robots in chronic strokeen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.neuroimage.2009.03.007-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19286464-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1053811909002389/1-s2.0-S1053811909002389-main.pdf?_tid=7288c0e3f29a65e2f106f2682d71c30e&acdnat=1333446961_b7d1f6282d58a06ad80716626e082385-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2009-
heal.abstractThe aim of this study was to investigate functional reorganization of motor systems by probing connectivity between motor related areas in chronic stroke patients using functional magnetic resonance imaging (fMRI) in conjunction with a novel MR-compatible hand-induced, robotic device (MR_CHIROD). We evaluated data sets obtained from healthy volunteers and right-hand-dominant patients with first-ever left-sided stroke > or =6 months prior and mild to moderate hemiparesis affecting the right hand. We acquired T1-weighted echo planar and fluid attenuation inversion recovery MR images and multi-level fMRI data using parallel imaging by means of the GeneRalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) algorithm on a 3 T MR system. Participants underwent fMRI while performing a motor task with the MR_CHIROD in the MR scanner. Changes in effective connectivity among a network of primary motor cortex (M1), supplementary motor area (SMA) and cerebellum (Ce) were assessed using dynamic causal modeling. Relative to healthy controls, stroke patients exhibited decreased intrinsic neural coupling between M1 and Ce, which was consistent with a dysfunctional M1 to Ce connection. Stroke patients also showed increased SMA to M1 and SMA to cerebellum coupling, suggesting that changes in SMA and Ce connectivity may occur to compensate for a dysfunctional M1. The results demonstrate for the first time that connectivity alterations between motor areas may help counterbalance a functionally abnormal M1 in chronic stroke patients. Assessing changes in connectivity by means of fMRI and MR_CHIROD might be used in the future to further elucidate the neural network plasticity that underlies functional recovery in chronic stroke patients.en
heal.journalNameNeuroimageen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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