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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Antoniou, A. | en |
| dc.contributor.author | Milonas, D. | en |
| dc.contributor.author | Kanakakis, J. | en |
| dc.contributor.author | Rokas, S. | en |
| dc.contributor.author | Sideris, D. A. | en |
| dc.date.accessioned | 2015-11-24T19:27:26Z | - |
| dc.date.available | 2015-11-24T19:27:26Z | - |
| dc.identifier.issn | 0160-9289 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22812 | - |
| dc.rights | Default Licence | - |
| dc.subject | Atrial Fibrillation/*physiopathology/therapy | en |
| dc.subject | Blood Pressure/physiology | en |
| dc.subject | Cardiac Pacing, Artificial | en |
| dc.subject | Diuretics/administration & dosage/therapeutic use | en |
| dc.subject | Electrocardiography | en |
| dc.subject | Feedback/*physiology | en |
| dc.subject | Furosemide/administration & dosage/therapeutic use | en |
| dc.subject | Heart Atria/*physiopathology | en |
| dc.subject | Heart Catheterization | en |
| dc.subject | Humans | en |
| dc.subject | Infusions, Intravenous | en |
| dc.subject | Middle Aged | en |
| dc.subject | Myocardial Contraction/*physiology | en |
| dc.title | Contraction-excitation feedback in human atrial fibrillation | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9134280 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/clc.4960200514/asset/4960200514_ftp.pdf?v=1&t=h2lhmodr&s=8a4e0e613dbe2136402234c2984b550d310b7288 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1997 | - |
| heal.abstract | BACKGROUND: Contraction-excitation feedback, that is, electrophysiologic changes that are caused or preceded by mechanical changes of the myocardium, has been extensively studied in the ventricles. The role of contraction-excitation feedback in the atria, and more particularly in the genesis and maintenance of atrial fibrillation, has been less adequately investigated. HYPOTHESIS: The aim of the present study was to determine whether increased right atrial pressure (RAP) facilitates the induction of atrial fibrillation (AF) in patients with a history of lone AF. METHODS: Sixteen patients with a history of paroxysmal AF but without structural heart disease were included in the study. All patients underwent electrophysiologic study at both a lower (3.1 +/- 2.0 mmHg) and (in 13 cases) a higher (6.4 +/- 2.5 mmHg) RAP. "Higher" was considered the pressure following rapid (in about 30 min) intravenous administration of normal saline or before the administration of a diuretic. RESULTS: Rapid atrial pacing induced AF in 19 of 29 attempts. At a lower pressure, rapid pacing induced brief (3 s to 3 min) AF in 3 of 16 patients, long-lasting (> 3 min) AF in 3 of 16 patients, and no AF in 10 of 16 patients. At a higher pressure, brief AF was induced in 3 of 10 patients in whom no AF could be induced at a lower pressure, and long-lasting AF in 10 patients in whom either brief AF (3 cases) or no AF (7 cases) was induced at a lower pressure. In 11 patients, in whom Wenckebach periodicity was determined at both higher and lower pressure, the critical cycle length at which atrioventricular block appeared was significantly (p < 0.001, paired t-test) longer (349.1 +/- 44.4 ms, i.e., +15.5 +/- 11.3 ms) at higher than at lower atrial pressure (333.6 +/- 41.0 ms). In nine patients, in whom Wenckebach periodicity was determined and two rhythms occurred at different pressures, the critical cycle length was 332.2 +/- 45.8 ms when associated with sinus rhythm, and significantly (p < 0.01) longer (344.4 +/- 48.0 ms, i.e., +12.2 +/- 8.3 ms) when associated with induction of AF. CONCLUSION: In patients with lone atrial fibrillation, modest increases in atrial pressure may facilitate the induction of atrial fibrillation. | en |
| heal.journalName | Clin Cardiol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Antoniou-1997-Contraction-excitati.pdf | 465.21 kB | Adobe PDF | View/Open Request a copy |
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