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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zigouris, A. | en |
| dc.contributor.author | Batistatou, A. | en |
| dc.contributor.author | Alexiou, G. A. | en |
| dc.contributor.author | Pachatouridis, D. | en |
| dc.contributor.author | Mihos, E. | en |
| dc.contributor.author | Drosos, D. | en |
| dc.contributor.author | Fotakopoulos, G. | en |
| dc.contributor.author | Doukas, M. | en |
| dc.contributor.author | Voulgaris, S. | en |
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.date.accessioned | 2015-11-24T19:26:45Z | - |
| dc.date.available | 2015-11-24T19:26:45Z | - |
| dc.identifier.issn | 1547-5646 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22756 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Age Factors | en |
| dc.subject | Aged | en |
| dc.subject | *Diskectomy | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Intervertebral Disc/*pathology | en |
| dc.subject | Intervertebral Disc Degeneration/*pathology/surgery | en |
| dc.subject | Intervertebral Disc Displacement/*pathology/surgery | en |
| dc.subject | Lumbar Vertebrae/*pathology/surgery | en |
| dc.subject | Male | en |
| dc.subject | Matrix Metalloproteinase 1/*analysis | en |
| dc.subject | Matrix Metalloproteinase 3/*analysis | en |
| dc.subject | Middle Aged | en |
| dc.subject | Statistics as Topic | en |
| dc.subject | Young Adult | en |
| dc.title | Correlation of matrix metalloproteinases-1 and -3 with patient age and grade of lumbar disc herniation | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.3171/2010.9.SPINE09935 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21184636 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2011 | - |
| heal.abstract | OBJECT: The authors studied the histological alterations and the expression of matrix metalloproteinase (MMP)-1 and MMP-3 in disc specimens of patients who had undergone operations for lumbar disc herniation. METHODS: Forty-three lumbar disc specimens were evaluated histopathologically for degenerative changes and immunohistochemical expression of MMP-1 and MMP-3. The observed degenerative changes provided a degenerative score that was applied in each patient. Sections of disc immunostained for MMP-1 and MMP-3 were evaluated semiquantitatively. Patients were categorized in 3 age groups: < 30 years, between 30 and 60 years, and > 60 years of age. The expression of MMP-1 and MMP-3 were correlated to patient's age, degenerative score, and grade of lumbar disc herniation. RESULTS: There was no statistically significant difference in the degenerative score between the age groups. Degenerative changes were more pronounced in greater grades of herniation (p < 0.0001). In the group of patients < 30 years of age there was a significant correlation between MMP-1 and MMP-3 expression and both degenerative score and herniation grade. For the group of patients 30-60 years of age, there was no significant difference between MMP-1 expression and degenerative score, but the correlation between MMP-1 expression and grade of herniation was significant. There was a significant correlation between MMP-3 expression and both degenerative score and herniation grade. Regarding the patients > 60 years of age, there was a significant correlation between MMP-1 and MMP-3 expression and both degenerative score and herniation grade. There was a significantly lower expression of both MMP-1 and MMP-3 in the group < 30 years of age compared with the other ages. No significant correlation was found in MMP-1 and MMP-3 expression between the groups of patients who were 30-60 and > 60 years of age. Interestingly, in age groups > 30 years, there were no statistically significant differences between the expression of MMP-1 and MMP-3, whereas in patients < 30 years of age the expression of MMP-3 was significantly lower than the expression of MMP-1. CONCLUSIONS: The expression of MMP-1 and MMP-3 were strongly correlated to the age of the patients and the grade of herniation. An important finding in this study is the differential expression of MMP-1 and MMP-3 between the age groups. In the young age group it appears that deregulation of MMP-1 expression is higher than that of MMP-3 in the pathogenesis of lumbar disc herniation. | en |
| heal.journalName | J Neurosurg Spine | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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