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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ioannou, M. | en |
| dc.contributor.author | Alissafi, T. | en |
| dc.contributor.author | Lazaridis, I. | en |
| dc.contributor.author | Deraos, G. | en |
| dc.contributor.author | Matsoukas, J. | en |
| dc.contributor.author | Gravanis, A. | en |
| dc.contributor.author | Mastorodemos, V. | en |
| dc.contributor.author | Plaitakis, A. | en |
| dc.contributor.author | Sharpe, A. | en |
| dc.contributor.author | Boumpas, D. T. | en |
| dc.contributor.author | Verginis, P. | en |
| dc.date.accessioned | 2015-11-24T19:26:12Z | - |
| dc.date.available | 2015-11-24T19:26:12Z | - |
| dc.identifier.issn | 1550-6606 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22703 | - |
| dc.rights | Default Licence | - |
| dc.title | Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.4049/jimmunol.1101816 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/22210912 | - |
| heal.identifier.secondary | http://www.jimmunol.org/content/188/3/1136 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2012 | - |
| heal.abstract | There is a need in autoimmune diseases to uncover the mechanisms involved in the natural resolution of inflammation. In this article, we demonstrate that granulocytic myeloid-derived suppressor cells (G-MDSCs) abundantly accumulate within the peripheral lymphoid compartments and target organs of mice with experimental autoimmune encephalomyelitis prior to disease remission. In vivo transfer of G-MDSCs ameliorated experimental autoimmune encephalomyelitis, significantly decreased demyelination, and delayed disease onset through inhibition of encephalitogenic Th1 and Th17 immune responses. Exposure of G-MDSCs to the autoimmune milieu led to up-regulation of the programmed death 1 ligand that was required for the G-MDSC-mediated suppressive function both in vitro and in vivo. Importantly, myeloid-derived suppressor cells were enriched in the periphery of subjects with active multiple sclerosis and suppressed the activation and proliferation of autologous CD4(+) T cells ex vivo. Collectively, this study revealed a pivotal role for myeloid-derived suppressor cells in the regulation of multiple sclerosis, which could be exploited for therapeutic purposes. | en |
| heal.journalName | J Immunol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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