Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22687
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGlantzounis, G. K.en
dc.contributor.authorYang, W.en
dc.contributor.authorKoti, R. S.en
dc.contributor.authorMikhailidis, D. P.en
dc.contributor.authorSeifalian, A. M.en
dc.contributor.authorDavidson, B. R.en
dc.date.accessioned2015-11-24T19:26:03Z-
dc.date.available2015-11-24T19:26:03Z-
dc.identifier.issn1381-6128-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22687-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectLiver/*blood supply/drug effects/metabolismen
dc.subjectLiver Diseases/*drug therapy/metabolismen
dc.subjectReperfusion Injury/*drug therapy/metabolismen
dc.subjectSulfhydryl Compounds/*physiology/therapeutic useen
dc.titleThe role of thiols in liver ischemia-reperfusion injuryen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16918419-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2006-
heal.abstractThiol-containing compounds have an essential role in many biochemical reactions due to their ability to be easily oxidised and then quickly regenerated. Main representatives are glutathione, lipoic acid and thioredoxin which are synthesised de novo in mammalian cells. N-acetylcysteine and Bucillamine are synthetic thiols which have been administered in experimental and clinical studies for treatment of conditions associated with oxidative stress. Ischemia and reperfusion (I/R) injury is characterised by significant oxidative stress, characteristic changes in the antioxidant system and organ injury leading to significant morbidity and mortality. I/R occurs in a variety of clinical settings such as liver resection, organ transplantation, haemorrhagic shock with fluid resuscitation, heart surgery, myocardial infarction followed by reperfusion and laparoscopic surgery. In these circumstances, the administration of antioxidant agents such as thiols, could provide protection from the harmful effects of I/R injury. However, the ability of thiol compounds to reduce free radicals is associated with the formation of thiyl radicals and the rate and efficiency of removal of thiyl radicals has a critical effect on antioxidant or prooxidant actions of thiols in the cells. The aim of this review is to present the mechanisms by which thiols act as antioxidants and signalling molecules and the experimental and clinical evidence regarding their role in I/R injury with a particular emphasis on liver I/R. The current evidence suggests that thiols ameliorate I/R injury and that their clinical significance should be further evaluated in large scale randomised clinical trials.en
heal.journalNameCurr Pharm Desen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Files in This Item:
There are no files associated with this item.


This item is licensed under a Creative Commons License Creative Commons