Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/22628Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Dimas, K. | en |
| dc.contributor.author | Demetzos, C. | en |
| dc.contributor.author | Vaos, B. | en |
| dc.contributor.author | Marselos, M. | en |
| dc.contributor.author | Kokkinopoulos, D. | en |
| dc.date.accessioned | 2015-11-24T19:25:30Z | - |
| dc.date.available | 2015-11-24T19:25:30Z | - |
| dc.identifier.issn | 0145-2126 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22628 | - |
| dc.rights | Default Licence | - |
| dc.subject | Antineoplastic Agents/*pharmacology | en |
| dc.subject | Benzopyrans/*pharmacology | en |
| dc.subject | Cell Division/*drug effects | en |
| dc.subject | DNA Replication/drug effects | en |
| dc.subject | DNA, Neoplasm/drug effects/metabolism | en |
| dc.subject | Electrophoresis, Agar Gel | en |
| dc.subject | Flow Cytometry | en |
| dc.subject | Humans | en |
| dc.subject | Leukemia/genetics/*pathology | en |
| dc.subject | Tumor Cells, Cultured | en |
| dc.title | Cytotoxic and antiproliferative effects of heptaacetyltiliroside on human leukemic cell lines | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10576507 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0145212699001241/1-s2.0-S0145212699001241-main.pdf?_tid=dc58f6ec9c95a81b971aed0cad595445&acdnat=1332742566_84b5ff7a592097a0a651fa811efb0a8b | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1999 | - |
| heal.abstract | The peracetylated derivative of kaempferol-3-O-beta-D-(6''-E-p-coumaroyl) glycopyranoside (tiliroside) (1a) was tested for its cytotoxic and cytostatic activity against several human leukemic cell lines. The significant cytotoxic activity of this derivative, prompted to an additional examination on some of the cell lines used. The effect on the uptake of [3H]thymidine as a marker of DNA synthesis and on the cell proliferation, was investigated as well as the morphology of the cells and the kind of death induced, using the Wright-Giemsa dye and horizontal agarose-gel electrophoresis. Flow cytometric experiments of 1a on some leukemic cell lines was also performed. Compound 1a showed a significant antiproliferative effect as soon as 1 h of continuous incubation at all cell lines tested. Cells were killed, through the process of apoptosis and the appearance of the apoptotic signs was time and dose-dependent, while from the flow cytometric experiments, a synchronisation (through a delay probably in the G(0/1) phase) of the cells seems to take place. | en |
| heal.journalName | Leuk Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Dimas-1999-Cytotoxic and antipr.pdf | 5.24 MB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License
