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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Meredith, E. J. | en |
| dc.contributor.author | Holder, M. J. | en |
| dc.contributor.author | Chamba, A. | en |
| dc.contributor.author | Challa, A. | en |
| dc.contributor.author | Drake-Lee, A. | en |
| dc.contributor.author | Bunce, C. M. | en |
| dc.contributor.author | Drayson, M. T. | en |
| dc.contributor.author | Pilkington, G. | en |
| dc.contributor.author | Blakely, R. D. | en |
| dc.contributor.author | Dyer, M. J. | en |
| dc.contributor.author | Barnes, N. M. | en |
| dc.contributor.author | Gordon, J. | en |
| dc.date.accessioned | 2015-11-24T19:24:44Z | - |
| dc.date.available | 2015-11-24T19:24:44Z | - |
| dc.identifier.issn | 1530-6860 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22521 | - |
| dc.rights | Default Licence | - |
| dc.subject | Antineoplastic Agents/*pharmacology | en |
| dc.subject | Apoptosis/drug effects | en |
| dc.subject | Burkitt Lymphoma/*chemistry/drug therapy | en |
| dc.subject | Cell Line, Tumor | en |
| dc.subject | Clomipramine/pharmacology | en |
| dc.subject | Fenfluramine/pharmacology | en |
| dc.subject | Fluoxetine/pharmacology | en |
| dc.subject | Humans | en |
| dc.subject | Lymphoma, B-Cell/*chemistry/drug therapy | en |
| dc.subject | N-Methyl-3,4-methylenedioxyamphetamine/pharmacology | en |
| dc.subject | P-Glycoprotein/analysis | en |
| dc.subject | Proto-Oncogene Proteins c-bcl-2/analysis/physiology | en |
| dc.subject | Psychotropic Drugs/*pharmacology | en |
| dc.subject | Serotonin Plasma Membrane Transport Proteins/*analysis/drug effects/physiology | en |
| dc.title | The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1096/fj.04-3477fje | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15870169 | - |
| heal.identifier.secondary | http://www.fasebj.org/content/early/2005/06/29/fj.04-3477fje.full.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2005 | - |
| heal.abstract | Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in Burkitt's lymphoma, we now detail its expression among a broad spectrum of B cell malignancy, while exploring additional SERT substrates for potential therapeutic activity. SERT was readily detected in derived B cell lines with origins as diverse as B cell precursor acute lymphoblastic leukemia, mantle cell lymphoma, diffuse large B cell lymphoma, and multiple myeloma. Concentration and timecourse kinetics for the antiproliferative and proapoptotic activities of the amphetamine derivatives fenfluramine (an appetite suppressant) and 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") revealed them as being similar to the endogenous indoleamine. A tricyclic antidepressant, clomipramine, instead mirrored the behavior of the selective serotonin reuptake inhibitor fluoxetine, both being effective in the low micromolar range. A majority of neoplastic clones were sensitive to one or more of the serotonergic compounds. Dysregulated bcl-2 expression, either by t(14;18)(q32;q21) translocation or its introduction as a constitutively active transgene, provided protection from proapoptotic but not antiproliferative outcomes. These data indicate a potential for SERT as a novel anti-tumor target for amphetamine analogs, while evidence is presented that the seemingly more promising antidepressants are likely impacting malignant B cells independently of the transporter itself. | en |
| heal.journalName | Faseb Journal | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Meredith-2005-The serotonin transp.pdf | 3.03 MB | Adobe PDF | View/Open Request a copy |
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