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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Antoniou, K. | en |
| dc.contributor.author | Papadopoulou-Daifotis, Z. | en |
| dc.contributor.author | Kafetzopoulos, E. | en |
| dc.date.accessioned | 2015-11-24T19:24:31Z | - |
| dc.date.available | 2015-11-24T19:24:31Z | - |
| dc.identifier.issn | 0166-4328 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22489 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Biogenic Monoamines/metabolism | en |
| dc.subject | Central Nervous System Stimulants/administration & dosage/*pharmacology | en |
| dc.subject | Dextroamphetamine/administration & dosage/*pharmacology | en |
| dc.subject | Excitatory Amino Acid Agonists/administration & dosage/*toxicity | en |
| dc.subject | Grooming/drug effects | en |
| dc.subject | Ibotenic Acid/administration & dosage/*toxicity | en |
| dc.subject | Injections | en |
| dc.subject | Male | en |
| dc.subject | Motor Activity/drug effects | en |
| dc.subject | Neostriatum/anatomy & histology/metabolism/*physiology | en |
| dc.subject | Oxidopamine | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Stereotyped Behavior/drug effects | en |
| dc.subject | *Sympathectomy, Chemical | en |
| dc.subject | Sympatholytics | en |
| dc.subject | Yawning/drug effects | en |
| dc.title | Differential alterations in basal and D-amphetamine-induced behavioural pattern following 6-OHDA or ibotenic acid lesions into the dorsal striatum | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9867227 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S016643289800014X/1-s2.0-S016643289800014X-main.pdf?_tid=66f60c47e78a633dcc920c0407660879&acdnat=1332923965_988ffd4ac0340eaf2d7f3637b9c8c528 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1998 | - |
| heal.abstract | It is well known that the corpus striatum is related to the sterotyped activation induced by several psychostimulants. In this study we analyzed the effects of 6-OHDA, in comparison with those of ibotenic acid lesions, into the dorsal striatum, on the behavioural pattern induced by saline or D-amphetamine treatment. A computerized technique for recording the animal motor activity was developed in order to define in a detailed way the behavioural profile in lesioned and sham-operated rats induced by the saline or D-amphetamine treatment. A 6-OHDA lesion into the dorsal striatum modified the basal behavioural pattern which was mainly characterized by reduced motor activation while ibotenic acid lesion affected the structure of the basal behavioral pattern. D-Amphetamine administration in 6-OHDA lesioned rats induced a behavioural stimulation, but a decreased motor and stereotyped activation was observed compared to the sham-operated animals treated with D-amphetamine. In contrast, D-amphetamine administration in the ibotenic acid-lesioned rats induced a motor and stereotyped activity which was not reduced compared to that seen after D-amphetamine treatment in sham-operated rats. These results suggest that these two types of lesion induced differential effects on the behavioural pattern either after saline or after D-amphetamine administration. Dopaminergic neurotransmission in the dorsal striatum plays a permissive role on the emergence of the behavioural responses, while the dorsal striatum circuitry plays a crucial role on the organization of the behavioural pattern. In addition, dopaminergic activity in this structure serves a primary control in the D-amphetamine-elicited motor activation or stereotypy, while the striatal structure is involved in the shaping of the D-amphetamine behavioural pattern. | en |
| heal.journalName | Behav Brain Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Antoniou-1998-Differential alterat.pdf | 513.39 kB | Adobe PDF | View/Open Request a copy |
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