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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22467
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dc.contributor.authorBai, M.en
dc.contributor.authorSkyrlas, A.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorKamina, S.en
dc.contributor.authorTsanou, E.en
dc.contributor.authorGrepi, C.en
dc.contributor.authorGalani, V.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:24:23Z-
dc.date.available2015-11-24T19:24:23Z-
dc.identifier.issn0893-3952-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22467-
dc.rightsDefault Licence-
dc.subject*Apoptosisen
dc.subjectB-Lymphocytes/chemistry/immunology/pathologyen
dc.subjectBH3 Interacting Domain Death Agonist Proteinen
dc.subjectCarrier Proteins/analysisen
dc.subjectCell Cycle Proteins/analysisen
dc.subjectCell Differentiationen
dc.subjectCell Divisionen
dc.subjectChi-Square Distributionen
dc.subjectDNA-Binding Proteins/analysisen
dc.subjectGerminal Center/chemistry/immunology/*pathologyen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectImmunophenotypingen
dc.subjectInterferon Regulatory Factorsen
dc.subjectLymphoma, B-Cell/immunology/metabolism/*pathologyen
dc.subjectLymphoma, Large B-Cell, Diffuse/immunology/metabolism/*pathologyen
dc.subjectMembrane Proteins/analysisen
dc.subjectNeprilysin/analysisen
dc.subjectProto-Oncogene Proteins/analysis/*biosynthesisen
dc.subjectProto-Oncogene Proteins c-bcl-2/analysisen
dc.subjectTranscription Factors/analysisen
dc.subjectbcl-2 Homologous Antagonist-Killer Proteinen
dc.subjectbcl-2-Associated X Proteinen
dc.subjectbcl-X Proteinen
dc.titleDiffuse large B-cell lymphomas with germinal center B-cell-like differentiation immunophenotypic profile are associated with high apoptotic index, high expression of the proapoptotic proteins bax, bak and bid and low expression of the antiapoptotic protein bcl-xlen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1038/modpathol.3800130-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15073604-
heal.identifier.secondaryhttp://www.nature.com/modpathol/journal/v17/n7/pdf/3800130a.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2004-
heal.abstractThe aim of this study was to analyze the relations between differentiation immunophenotypes and the status of apoptosis and proliferation in diffuse large B-cell lymphomas. Therefore, the bcl6/CD10/MUM1/CD138 differentiation immunophenotypic profiles were studied in relation to (a) the apoptotic index, (b) the apoptosis-associated bcl2 family proteins bcl2, bcl-xl, bax, bak, bad and bid, (c) the proliferation index (Ki67) and (d) the cell cycle proteins cyclin A, cyclin B1, cyclin D3, cyclin E, p53, Rb, p16 and p27 in 79 cases of diffuse large B-cell lymphomas. Two major differentiation immunophenotypic profiles were distinguished: the germinal center B-cell-like profile; 31 cases (bcl6+/CD10+/-/MUM1-/CD138-: 29 cases and bcl6-/CD10+/MUM1-/CD138-: two cases) and the nongerminal center B-cell-like profile (bcl6+/-/CD10-/MUM1+/CD138-); 48 cases. The expression of bax, bak and bid and the apoptotic index were significantly higher in the germinal center B-cell-like profile than in the nongerminal center B-cell-like profile (P=0.045, 0.018, 0.003 and 0.034, respectively). In contrast, the expression of bcl-xl was significantly lower in the germinal center B-cell-like profile than in the nongerminal center B-cell-like profile (P=0.026). The expression of bcl6 and CD10 showed significant positive correlation with the expression of bax (r=0.659, P<0.001 and r=0.240, P=0.033, respectively), bak (r=0.391, P<0.001 and r=0.233, P=0.039, respectively) and bid (r=0.652, P<0.001 and r=0.238, P=0.035, respectively) and significant negative correlation with the expression of bcl-xl (r=-0.536, P<0.001 and r=-0.250, P=0.029, respectively). The expression of MUM1 showed significant negative correlation with the expression of bax (r=-0.276, P=0.014) and bid (r=-0.266, P=0.018) and significant positive correlation with the expression of bcl-xl (r=0.238, P=0.037). The above findings indicate that diffuse large B-cell lymphomas with germinal center B-cell-like immunophenotypic profile are associated with increased apoptosis status, high expression of the proapoptotic proteins bax, bak and bid and low expression of the antiapoptotic protein bcl-xl.en
heal.journalNameMod Patholen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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