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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22458
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dc.contributor.authorManousou, P.en
dc.contributor.authorDhillon, A. P.en
dc.contributor.authorIsgro, G.en
dc.contributor.authorCalvaruso, V.en
dc.contributor.authorLuong, T. V.en
dc.contributor.authorTsochatzis, E.en
dc.contributor.authorXirouchakis, E.en
dc.contributor.authorKalambokis, G.en
dc.contributor.authorCross, T. J.en
dc.contributor.authorRolando, N.en
dc.contributor.authorO'Beirne, J.en
dc.contributor.authorPatch, D.en
dc.contributor.authorThornburn, D.en
dc.contributor.authorBurroughs, A. K.en
dc.date.accessioned2015-11-24T19:24:20Z-
dc.date.available2015-11-24T19:24:20Z-
dc.identifier.issn1527-6473-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22458-
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBiopsyen
dc.subjectChilden
dc.subjectCollagen/*metabolismen
dc.subjectEnd Stage Liver Disease/pathology/physiopathology/*surgery/virologyen
dc.subjectFemaleen
dc.subjectHepatic Veins/physiopathologyen
dc.subjectHepatitis C/complications/metabolism/pathology/physiopathology/*surgeryen
dc.subjectHumansen
dc.subject*Image Interpretation, Computer-Assisteden
dc.subjectKaplan-Meier Estimateen
dc.subjectLiver/blood supply/*metabolism/pathology/*surgery/virologyen
dc.subjectLiver Cirrhosis/metabolism/pathology/physiopathology/*surgery/virologyen
dc.subjectLiver Transplantation/*adverse effectsen
dc.subjectLondonen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPredictive Value of Testsen
dc.subjectProportional Hazards Modelsen
dc.subjectROC Curveen
dc.subjectRecurrenceen
dc.subjectRetrospective Studiesen
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectSensitivity and Specificityen
dc.subjectTime Factorsen
dc.subjectVenous Pressureen
dc.subjectYoung Adulten
dc.titleDigital image analysis of liver collagen predicts clinical outcome of recurrent hepatitis C virus 1 year after liver transplantationen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1002/lt.22209-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21280191-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/lt.22209/asset/22209_ftp.pdf?v=1&t=h0ulywnc&s=60bca922865a410c028501b6199dd1c5156dc60b-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2011-
heal.abstractClinical outcomes of recurrent hepatitis C virus after liver transplantation are difficult to predict. We evaluated collagen proportionate area (CPA), a quantitative histological index, at 1 year with respect to the first episode of clinical decompensation. Patients with biopsies at 1 year after liver transplantation were evaluated by Ishak stage/grade, and biopsy samples stained with Sirius red for digital image analysis were evaluated for CPA. Cox regression was used to evaluate variables associated with first appearance of clinical decompensation. Receiver operating characteristic (ROC) curves were also used. A total of 135 patients with median follow-up of 76 months were evaluated. At 1 year, median CPA was 4.6% (0.2%-36%) and Ishak stage was 0-2 in 101 patients, 3-4 in 23 patients, and 5-6 in 11 patients. Decompensation occurred in 26 (19.3%) at a median of 61 months (15-138). Univariately, CPA, tacrolimus monotherapy, and Ishak stage/grade at 1 year were associated with decompensation; upon multivariate analysis, only CPA was associated with decompensation (P = 0.010; Exp(B) = 1.169; 95%CI, 1.037-1.317). Area under the ROC curve was 0.97 (95%CI, 0.94-0.99). A cutoff value of 6% of CPA had 82% sensitivity and 95% specificity for decompensation. In the 89 patients with hepatic venous pressure gradient (HVPG) measurement, similar results were obtained. When both cutoffs of CPA > 6% and HVPG >/= 6 mm Hg were used, all patients decompensated. Thus, CPA at 1-year biopsy after liver transplantation was highly predictive of clinical outcome in patients infected with hepatitis C virus who underwent transplantation, better than Ishak stage or HVPG.en
heal.journalNameLiver Transplen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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