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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kanavaros, P. | en |
| dc.contributor.author | Gaulard, P. | en |
| dc.contributor.author | Charlotte, F. | en |
| dc.contributor.author | Martin, N. | en |
| dc.contributor.author | Ducos, C. | en |
| dc.contributor.author | Lebezu, M. | en |
| dc.contributor.author | Mason, D. Y. | en |
| dc.date.accessioned | 2015-11-24T19:24:14Z | - |
| dc.date.available | 2015-11-24T19:24:14Z | - |
| dc.identifier.issn | 0002-9440 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22442 | - |
| dc.rights | Default Licence | - |
| dc.subject | *Antigens, CD | en |
| dc.subject | Antigens, CD79 | en |
| dc.subject | Humans | en |
| dc.subject | Immunoglobulins/*metabolism | en |
| dc.subject | Immunophenotyping | en |
| dc.subject | Lymphoid Tissue/metabolism | en |
| dc.subject | Lymphoma, B-Cell/*metabolism | en |
| dc.subject | Lymphoma, Large B-Cell, Diffuse/*metabolism | en |
| dc.subject | Lymphoma, T-Cell/metabolism | en |
| dc.subject | Mediastinal Neoplasms/*metabolism | en |
| dc.subject | Membrane Glycoproteins/*metabolism | en |
| dc.subject | Receptors, Antigen, B-Cell/*metabolism | en |
| dc.title | Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomas | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7887454 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1995 | - |
| heal.abstract | Mediastinal large B cell lymphomas are uncommon neoplasms that are thought to originate from thymic B cells. An unusual feature of these neoplasms is that they often lack surface immunoglobulin (Ig), a molecule ubiquitously expressed by most mature B cells. In the present study we have analyzed 12 cases of mediastinal large B cell lymphoma for the expression of the mb-1/CD79a polypeptide. This is a component, together with B29/CD79b, of a heterodimer that is associated with surface Ig on normal B cells. Our aim was to see whether loss of Ig in this type of lymphoma is associated with loss of the accompanying CD79a molecule. We have also evaluated 128 B cell lymphomas of other categories to see whether any of them show discordance between mb-1 and Ig expression and analyzed 30 T cell lymphomas as Ig-negative controls. We found that 5 of the 7 mediastinal large B cell lymphomas with interpretable staining results for both mb-1 and Ig, lack Ig but expressed CD79a (mb-1). This phenotype was very rare in other categories of B cell lymphoma, being found among 110 cases in only 5 cases that were all follicular lymphoma. The remaining 105 B cell lymphomas displayed mb-1+/Ig+ phenotype. All 30 T cell lymphomas were mb-1 negative. We conclude that discordant mb-1/Ig expression occurs commonly in mediastinal large B cell lymphomas. In addition, the finding that 11 of 12 of these neoplasms express a phenotype (CD10-, CD19+, CD20+, CD21-, CD22+, CD23-/+) that is very similar to that described for thymic medullary B cells reinforces the idea that most mediastinal large B cell lymphomas are of thymic B cell origin. The correlation between mb-1 and Ig staining patterns in B cell lymphomas of other categories reveals that in the majority (90%), expression of the antigen receptor complex parallels that of mature B cells. These data therefore confirm that the expression of the mb-1 protein provides independent strong evidence for the B lineage of lymphomas and may be used for their routine phenotypic characterization. | en |
| heal.journalName | Am J Pathol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kanavaros-1995-discordant expression of.pdf | 2.16 MB | Adobe PDF | View/Open Request a copy |
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