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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22363
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dc.contributor.authorMarelli, L.en
dc.contributor.authorXirouchakis, E.en
dc.contributor.authorKalambokis, G.en
dc.contributor.authorCholongitas, E.en
dc.contributor.authorHamilton, M. I.en
dc.contributor.authorBurroughs, A. K.en
dc.date.accessioned2015-11-24T19:23:48Z-
dc.date.available2015-11-24T19:23:48Z-
dc.identifier.issn1468-3288-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22363-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAzathioprine/administration & dosageen
dc.subjectCholangitis, Sclerosing/*complications/surgeryen
dc.subjectColectomyen
dc.subjectColitis, Ulcerative/*complications/drug therapy/surgeryen
dc.subjectColonic Neoplasms/etiologyen
dc.subjectDisease Progressionen
dc.subjectDrug Administration Scheduleen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectGlucocorticoids/administration & dosageen
dc.subjectHumansen
dc.subjectImmunosuppressive Agents/administration & dosageen
dc.subjectLiver Transplantationen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrognosisen
dc.titleDoes the severity of primary sclerosing cholangitis influence the clinical course of associated ulcerative colitis?en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1136/gut.2010.235408-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21402617-
heal.identifier.secondaryhttp://gut.bmj.com/content/60/9/1224-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2011-
heal.abstractBACKGROUND AND AIMS: Ulcerative colitis (UC) associated with primary sclerosing cholangitis (PSC) is usually clinically mild. The aim of the study was to assess whether there is an association between severity of PSC and activity of UC, comparing the course of UC in patients with PSC not needing liver transplantation (LT) and those eventually transplanted. METHODS: Between 1990 and 2009, 96 consecutive patients with PSC/UC were seen in the authors' institution. Data were evaluated from a database regarding UC activity (median follow-up 144 months). Follow-up was censored at time of LT or last clinical review. RESULTS: Patients with PSC/UC were divided into two groups: 46 did not need LT (no-LT) and 50 were transplanted (LT). There were no significant differences concerning duration of UC or PSC and extent of UC. The LT group had significantly (p=0.002) more clinically quiescent UC compared with the no-LT group. The LT group had fewer UC flare-ups (p=0.04) and required fewer steroid courses (p=0.025) with shorter duration (p=0.022) and less use of azathioprine (p=0.003). There was an increased need for surgery in the no-LT group (p=0.006). Colon carcinoma and high grade dysplasia were more frequent in the no-LT group (p=0.004). The no-LT group had increased inflammation in the colonic mucosa at histology (p=0.011), but without visual difference at colonoscopy. CONCLUSIONS: Clinically progressive PSC requiring LT is associated with a milder course of UC (reduced disease activity and less use of steroids, azathioprine and surgery). This is paralleled by less histological activity and reduced incidence of dysplasia and colon carcinoma.en
heal.journalNameGuten
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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