Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/22246Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sohal, R. S. | en |
| dc.contributor.author | Marzabadi, M. R. | en |
| dc.contributor.author | Galaris, D. | en |
| dc.contributor.author | Brunk, U. T. | en |
| dc.date.accessioned | 2015-11-24T19:23:06Z | - |
| dc.date.available | 2015-11-24T19:23:06Z | - |
| dc.identifier.issn | 0891-5849 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22246 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Cells, Cultured | en |
| dc.subject | Female | en |
| dc.subject | Fluorescence | en |
| dc.subject | Heart/drug effects | en |
| dc.subject | Lipofuscin/*metabolism | en |
| dc.subject | Male | en |
| dc.subject | Microscopy, Electron | en |
| dc.subject | Myocardium/*metabolism/ultrastructure | en |
| dc.subject | Organelles/metabolism | en |
| dc.subject | Oxidation-Reduction | en |
| dc.subject | Oxygen/*pharmacology | en |
| dc.subject | Pigments, Biological/*metabolism | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Inbred Strains | en |
| dc.subject | Spectrometry, Fluorescence | en |
| dc.title | Effect of ambient oxygen concentration on lipofuscin accumulation in cultured rat heart myocytes--a novel in vitro model of lipofuscinogenesis | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/2912825 | - |
| heal.identifier.secondary | http://www.sciencedirect.com/science/article/pii/089158498990155X | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1989 | - |
| heal.abstract | The objective of this study was to elucidate the factors involved in the accumulation of lipofuscin in post-mitotic cells. The hypothesis that oxidative stress accelerates the rate of lipofuscin accumulation was tested by examining the effects of 5%, 20%, and 40% ambient oxygen concentration on lipofuscin content in cultured rat cardiac myocytes. Lipofuscin was quantified by microspectrofluorometry at 7 and 12 days of in vitro age. Lipofuscin-emitted yellow autofluorescence increased in direct relationship to ambient oxygen concentration with age. Transmission electron microscopic examination of the cells after 3, 8, and 12 days in culture indicated a progressive time and oxygen dependent increase in the frequency and size of lipofuscin organelles. The results are interpreted to suggest that oxidative stress is one of the causal factors in the accumulation of lipofuscin. | en |
| heal.journalName | Free Radic Biol Med | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Galaris-1989-effect of ambient.pdf | 1.13 MB | Adobe PDF | View/Open Request a copy |
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